Effect of altered thyroid status on neurotrophin gene expression during postnatal development of the mouse cerebellum

Thyroid : Official Journal of the American Thyroid Association
Noriyuki KoibuchiW W Chin

Abstract

Thyroid hormone (TH) plays an important role in brain development. The rodent cerebellum has been an excellent model for the study of the molecular mechanisms of TH action in brain. However, most studies have utilized the rat rather than the mouse. Considering the usefulness of mice with regard to diverse genetic models, the study of TH effect on mouse cerebellar development is needed. Thus, we examined the effect of perinatal hypothyroidism on the expression of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) genes, which play critical roles in cerebellar development. Newborn mice were rendered hypothyroid by administering methimazole and perchlorate in drinking water to their mothers. The growth of hypothyroid mice was retarded, which was reversed by daily thyroxine administration. NT-3 and BDNF gene expression was depressed in the perinatal hypothyroid cerebellum. Furthermore, the expression of retinoid-receptor-related orphan nuclear hormone receptor-alpha (RORalpha), an orphan nuclear receptor that plays critical roles in Purkinje cell development, was also decreased. Morphologically, disappearance of the external granule cell layer was retarded and arborization of Purkinje cell dendrite was decreased, ev...Continue Reading

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Citations

Jul 25, 2009·Archives of Toxicology·Naomi TsukueKen Takeda
Oct 17, 2008·The Cerebellum·Noriyuki Koibuchi
Jan 9, 2009·The Cerebellum·Noriyuki Koibuchi
Jul 20, 2002·Brain Research. Developmental Brain Research·Junko Kimura-KurodaYoichiro Kuroda
Sep 21, 2002·Molecular and Cellular Endocrinology·Françoise Chantoux, Jacques Francon
Jul 29, 2010·Neural Development·Fatiha BoukhtoucheJean Mariani
May 17, 2006·Endocrine Journal·Noriyuki Koibuchi, Toshiharu Iwasaki
Dec 19, 2012·Neuroscience·A Shulga, C Rivera
Oct 27, 2011·Biochemical and Biophysical Research Communications·Hongyan DongMichael G Wade
May 23, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rohit A SinhaSanghamitra Bandyopadhyay
May 18, 2005·Journal of Neuroscience Research·Masaki TakahashiTomoko Tashiro
Mar 29, 2013·European Journal of Pain : EJP·I G N AlvesV J de Santana-Filho
Feb 24, 2009·Brain Research·Jill M WeimerDavid A Pearce
Feb 15, 2005·Brain Research. Developmental Brain Research·Junko Kimura-KurodaYoichiro Kuroda
Feb 26, 2016·Thyroid : Official Journal of the American Thyroid Association·Izuki AmanoNoriyuki Koibuchi
Aug 11, 2012·Autonomic Neuroscience : Basic & Clinical·Sheyla Oliveira SantosDaniel Badauê-Passos
Dec 5, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kelsey KlinefelterChristine Perdan Curran
Feb 23, 2018·Molecular Biology of the Cell·Baojin DingDaniel L Kilpatrick
Jun 21, 2019·The Cerebellum·Ana Paula Bergamo AraujoFlávia Carvalho Alcantara Gomes
Oct 7, 2015·The Cerebellum·Ketty LetoRichard Hawkes
Aug 10, 2021·Endocrinology and Metabolism·Sumiyasu IshiiNoriyuki Koibuchi

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