Effect of altering the proportion of dietary fat and carbohydrate on exercise gas exchange in normal subjects

The American Review of Respiratory Disease
D Y SueK Wasserman

Abstract

A low proportion of dietary calories as carbohydrate has been suggested for patients with chronic obstructive pulmonary disease, because oxidation of carbohydrate (CHO) compared to fat results in greater CO2 production (VCO2) and, at the same arterial PCO2 (PaCO2), higher alveolar and minute ventilation (VE) and increased dyspnea. We hypothesized that a low CHO-high fat diet, although reducing VCO2 and VE at rest, might result in only a small change in VCO2 and VE during exercise. Eight healthy volunteers were randomized to receive for 24 h either isocaloric diets containing 10% or 70% of total calories from CHO (remainder of nonprotein calories from fat). Measurements of VCO2, VE, and respiratory gas exchange ratio (R) were made at rest and during constant work rate cycle exercise below the anaerobic threshold. Five to seven days later, the alternate diet was given and the studies were repeated. At rest, mean VCO2 and R were significantly lower after the low CHO diet compared to the high CHO diet. Mean resting VE was less but not significantly (high CHO 9.6 [0.7] versus low CHO 8.7 [0.8] L/min, mean [SEM]). During exercise, mean VCO2 and R were significantly less after the low CHO diet, but mean VE was only slightly smaller an...Continue Reading

References

Apr 11, 1980·JAMA : the Journal of the American Medical Association·J AskanaziJ M Kinney
May 1, 1981·Anesthesiology·J AskanaziJ M Kinney

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Citations

Mar 22, 2005·European Journal of Applied Physiology·Peter Lindholm, Mikael Gennser
Aug 1, 2015·Respiratory Physiology & Neurobiology·Tomohiko KisakaKarlman Wasserman
Jun 27, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Keiji HayashiYuichi Suzuki
Sep 25, 2019·Journal of the American College of Nutrition·Hunter L ParisTimothy D Mickleborough
Nov 2, 2019·Advances in Therapy·Denis E O'DonnellJ Alberto Neder
Apr 4, 2021·Nutrients·Elena GangitanoCarla Lubrano
Apr 24, 2001·Clinics in Chest Medicine·S K Pingleton

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