PMID: 1213966Dec 1, 1975Paper

Effect of alveolar liquid on distribution of blood flow in dog lungs

Journal of Applied Physiology
A L MuirW Chernecki

Abstract

Previous studies have shown that a shift in blood flow away from edematous regions does not occur until the alveoli contain liquid. The present experiments were designed to examine the separate effect of air space liquid, air space plus interstitial liquid, and reduced lung volume on blood flow. We found that reduced lung volume was not associated with significant changes in blood flow and that no systematic change in blood flow occurred when alveoli were filled with isosmotic liquid (autologous plasma). However, when hyposmotic liquid (dilute plasma) was instilled so that both the air space and the alveolar wall interstitial space were filled, blood flow was systematically reduced. This suggested that interstitial liquid was responsible raising vascular resistance in these experiments and that it might also be important in raising local vascular resistance in pulmonary edema. This latter hypothesis was tested in isolated perfused lobes where rapid freezing and quantitative histology showed that the number of open capillaries was significantly reduced in the liquid-filled alveoli (P less than 0.001). These observations suggest that interstitial pressure rises in pulmonary edema with the result that the transmural pressure of th...Continue Reading

Citations

Jan 1, 1989·Intensive Care Medicine·T HachenbergP Lawin
Apr 1, 1993·The American Review of Respiratory Disease·H BachofenE R Weibel
Jul 8, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·John R SprattGabriel Loor
Feb 27, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Takashige MiyaharaJames C Parker
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·T HachenbergM Wendt
Apr 1, 1990·Acta Anaesthesiologica Scandinavica·T HachenbergM Wendt

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