Effect of amelogenin extracellular matrix protein and compression on hard-to-heal venous leg ulcers: follow-up data

Journal of Wound Care
Marco RomanelliJ L Lazaro

Abstract

To undertake a follow-up of patients with hard-to-heal venous leg ulcers (VLUs) who had participated in a randomised controlled trial in which they had been treated with either compression therapy in combination with amelogenin extracellular matrix protein or compression therapy alone for 12 weeks or until their ulcers had healed, whichever occurred first. Patients were randomised to receive either high compression therapy plus amelogenin (n=42) or high compression therapy alone (n=41) for a period up to and including 12 weeks. The method and initial findings are detailed in an earlier paper. Twelve weeks after the final visit, the patients were followed up and the wounds were re-evaluated. The initial results demonstrated clinically and statistically significant benefits for the patients in the amelogenin group. The results of the follow-up showed that the successful healing response had been maintained. Significantly more patients continued to show a reduction in ulcer size from baseline in the amelogenin-treated group versus the control group (p=0.02), and there was a statistically significant (p=0.01) larger reduction in the amelogenin-treated group. This group also had a significantly (p=0.02) higher percentage of patients...Continue Reading

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Citations

Mar 21, 2009·The British Journal of Dermatology·S AlmqvistP Thomsen
Jul 25, 2009·Orthodontics & Craniofacial Research·S P LyngstadaasJ E Reseland
Jul 10, 2013·International Wound Journal·Keith HardingZee Upton
Aug 6, 2015·Advances in Wound Care·Neill J Turner, Stephen F Badylak
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Dec 16, 2016·The Cochrane Database of Systematic Reviews·Maggie J WestbyNicky Cullum
Mar 8, 2011·Journal of Wound Care·S AlmqvistM S Agren
Jun 16, 2018·The Cochrane Database of Systematic Reviews·Gill NormanJo C Dumville
Jan 19, 2010·British Journal of Nursing : BJN·Emma BondJane Pragnell
Oct 24, 2017·Frontiers in Chemistry·Angela CapolupoMaria C Monti
Apr 21, 2009·British Journal of Nursing : BJN·Paul Chadwick, Claire Acton

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