Effect of amino acid infusion on potassium serum levels in neuroendocrine tumour patients treated with targeted radiopeptide therapy.

European Journal of Nuclear Medicine and Molecular Imaging
Giampiero GiovacchiniFlavio Forrer

Abstract

Administration of positively charged amino acids has been introduced to reduce the nephrotoxicity of targeted radiopeptide therapy (TRT). However, the amino acid solution may have side effects, including hyperkalaemia. The aim of this study was to evaluate the frequency and the magnitude of hyperkalaemia in neuroendocrine tumour (NET) patients undergoing TRT. Enrolled in the study were 31 patients with NET eligible for TRT with [(90)Y-DOTA(0),Tyr(3)]octreotide ((90)Y-DOTATOC). Their mean age was 54 ± 14 years. Of these 31 patients, 21 (67%) were referred for the first treatment cycle, while 10 (33%) were referred for a subsequent therapy cycle. Patients were treated with therapeutic doses of (90)Y-DOTATOC ranging from 7,030 to 35,520 MBq. To inhibit tubular reabsorption of (90)Y-DOTATOC, 1 l of physiological saline solution containing 25 g of arginine hydrochloride and 25 g of lysine hydrochloride was given over 4 h starting 1 h before (90)Y-DOTATOC injection. All patients underwent a standard biochemical blood analysis at baseline, and 4 h and 24 h after the beginning of the amino acid infusion. ANOVA repeated measures showed a significant overall effect on K(+) levels over time (F = 118.2, df = 2, P < 0.0001). Mean serum leve...Continue Reading

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Citations

Feb 8, 2013·European Journal of Nuclear Medicine and Molecular Imaging·L BodeiJohn J Zaknun
Jul 19, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Raghava KashyapRodney J Hicks
Jul 23, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Chaker Ben SalemHoussem Hmouda
Aug 21, 2014·Annals of Nuclear Medicine·Rudolf A WernerKen Herrmann
Jun 23, 2016·SpringerPlus·Asunción CremadesRafael Peñafiel
Nov 5, 2011·Journal of Clinical Anesthesia·Arna BanerjeeAnn Walia
Nov 10, 2013·Postgraduate Medicine·W Frank PeacockClaudio Ronco
May 4, 2017·AJR. American Journal of Roentgenology·Hossein Jadvar

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