PMID: 5914250Sep 1, 1966

Effect of amino acids on sugar absorption

The Journal of Physiology
J T HindmarshG Wiseman


1. Sacs of everted mid-small intestine of the hamster have been used to study the effect of amino acids on sugar absorption.2. The sugars employed were D-glucose, D-galactose, 3-O-methyl-D-glucose, D-fucose, L-glucose, alpha-glucoheptose, L-fucose, D-mannose and L-sorbose. The amino acids were L- and D-histidine, L- and D-methionine, L- and D-alanine, L- and D-valine, L- and D-glutamic acid, L-leucine, L-proline, L-ornithine and L-aspartic acid.3. Actively absorbed amino acids considerably inhibit the transport of actively absorbed sugars. The results give support for the view that D-histidine and L-glucose are actively transferred. Passively absorbed amino acids and sugars are not involved.4. As L-glutamic and L-aspartic acids in the mucosal fluid have no inhibitory effect on D-glucose absorption, although mucosal fluid L-alanine is quite potent, the step at which the latter exerts its inhibitory action must be before that at which the intracellular transamination of L-glutamic and L-aspartic acids occurs. It would seem likely, therefore, that L-alanine interferes with the process by which epithelial cells capture and concentrate sugars at the luminal border.5. More than one active transfer system may exist for D-glucose.6. Th...Continue Reading


Dec 1, 1968·European Journal of Biochemistry·J W Robinson
May 4, 1968·Nature·R J Neale, G Wiseman
Jan 1, 1971·Pflügers Archiv : European journal of physiology·J W Robinson, F Alvarado
May 31, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Yo Tsuchiya, Koichi Kawamata
Apr 15, 1969·Klinische Wochenschrift·D M Matthews

Related Concepts

Glutamic Acids
Intestinal Absorption
Ornithine Monoacetate, (L)-Isomer

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