PMID: 8971904Dec 1, 1996Paper

Effect of aminoglycoside therapy on renal function in full-term infants

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
S AndronikouZoe L Papadopoulou

Abstract

The effect of aminoglycosides on renal function was evaluated in 30 full-term infants who were treated within 24 h of birth with either amikacin (10 infants, group A), gentamicin (9 infants, group B), or netilmicin (10 infants, group C). Renal function was assessed before, during, and 48 h after discontinuation of therapy by measuring the plasma creatinine concentration (PCr), the fractional excretion of sodium (FENa), potassium, magnesium, phosphate (FEP), uric acid, and the urinary excretion of calcium (UCA/UCr ratio) immediately before (trough) and after (peak) the infusion of the aminoglycosides. The results were compared with 10 control newborns who did not receive antibiotics. Significant alterations in renal function were observed only during therapy with gentamicin (group B). These consisted of a sustained elevation of FENa and UCa/UCr ratio throughout therapy, a latent increase in FEP on the 7th day (P < 0.05), and lack of the normal postnatal decline of PCr in 3 of 9 infants (P < 0.01). These abnormalities persisted up to 2 days after discontinuation of therapy. Therapeutic doses of gentamicin may result in significant electrolyte disturbances in sick full-term infants.

Citations

Dec 24, 2008·European Journal of Clinical Pharmacology·Gian Maria Pacifici
Aug 10, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sevinç TugayAyşe Sevim Gökalp
Jan 26, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Arpitha ChiruvoluGregory L Jackson
Oct 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·A NarendraJ Beattie
Mar 2, 2012·American Journal of Nephrology·Chien-Te LeeYeong-Hau H Lien
May 21, 2005·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M S Ghuysen
Oct 26, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·J IbrahimN Hanna
Mar 24, 2011·Reproductive Sciences·Lina GubhajuM Jane Black
Aug 17, 2004·Scandinavian Journal of Infectious Diseases·Claus KlingenbergTrond Flaegstad
May 17, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gregory L JacksonWilliam D Engle

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