Abstract
Aminoguanidine, which prevents formation of advanced glycation end products and is a relatively selective potent inhibitor of the inducible (versus constitutive) isoform(s) of nitric oxide synthase, has been reported to ameliorate structural and functional abnormalities in peripheral somatic nerves in rats with streptozocin (STZ)-induced diabetes. In the present studies, the effects of aminoguanidine treatment on ultrastructural changes in the autonomic nervous system of rats with STZ-induced diabetes were examined. The frequency of neuroaxonal dystrophy, the neuropathological hallmark of sympathetic autonomic neuropathy in diabetic rats, increased 9- to 11-fold in the superior mesenteric ganglia of 7- and 10-month STZ-diabetic rats compared with that in age-matched controls. Administration of aminoguanidine continuously from the time of induction of diabetes at a dose equal to or in excess of that providing a salutary effect in the diabetic somatic peripheral nervous system did not alter the severity of diabetes as assessed by plasma glucose level, 24-h urine volume, and levels of glycated hemoglobin. Chronic aminoguanidine therapy did not diminish the frequency or affect the ultrastructural appearance of neuroaxonal dystrophy...Continue Reading
Citations
Oct 21, 2006·Journal of Neural Transmission·P Riederer, S Hoyer
Oct 11, 2012·Experimental Diabetes Research·Nima TirganMassoud Motamedi
Jul 23, 2005·Annals of the New York Academy of Sciences·Norman E CameronMary A Cotter
May 1, 2007·Muscle & Nerve·Douglas W Zochodne
Mar 1, 2006·Diabetes/metabolism Research and Reviews·Rodica Pop-BusuiMartin Stevens
Jan 3, 2013·Diabetes, Obesity & Metabolism·L EngelenC G Schalkwijk
Sep 14, 1999·The American Journal of Medicine·A I Vinik
Sep 22, 2006·Autonomic Neuroscience : Basic & Clinical·Hannah R ShottonJill Lincoln
Sep 19, 2006·Pathologie-biologie·J Peyroux, M Sternberg
Jun 25, 2005·Experimental Eye Research·Takatoshi KobayashiTsunehiko Ikeda
Aug 17, 2004·The Medical Clinics of North America·A I Vinik, Anahit Mehrabyan
Feb 1, 1997·Postgraduate Medicine·N J Bohannon
Aug 9, 2006·European Journal of Clinical Investigation·K-C ChangY-Z Tseng
Mar 9, 2006·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Emile AndriambelosonNoelle Callizot
Dec 1, 1996·Journal of Neurocytology·R E Schmidt
Dec 13, 2000·Diabetes/metabolism Research and Reviews·K SugimotoA A Sima
Oct 20, 2018·Nutrition & Metabolism·Jie-Hua ChenXuguang Zhang
Apr 7, 2000·Brain Research·K ShinpoK Tashiro
Oct 22, 2003·Archives of Biochemistry and Biophysics·Paul J Thornalley