PMID: 10486696Sep 16, 1999Paper

Effect of amlodipine on exercise-induced platelet activation in patients affected by chronic stable angina

Clinical Cardiology
V SanguigniA Strano

Abstract

Literature concerning exercise-induced platelet activation in chronic stable angina is somewhat confusing. The reason lies in the type of exercise as well as in methodological problems. A powerful, recently introduced procedure to detect platelet activation is flow cytometry. Platelet response to activating factors is mediated by calcium uptake; however, calcium antagonist effect on platelet activity is still unclear. The study was undertaken to investigate exercise-induced platelet activation before and after treatment with amlodipine in chronic stable angina. Twenty patients with chronic stable angina were entered into the study. Each subject underwent a symptom-limited cycloergometer stress test following a washout period of 2 weeks. Blood samples were collected before and immediately after exercise. All subjects were then randomized into two groups of 10 patients each, with Group 1 and Group 2 taking amlodipine 10 mg/day, and placebo for 4 weeks, respectively. They subsequently underwent a second exercise stress test, and blood samples were obtained before and immediately after exercise. Flow-cytometric evaluation of platelet activity was performed in order to recognize GMP-140 expression on platelet membrane. Strenuous exe...Continue Reading

References

Dec 22, 1979·Lancet·P C Elwood, P M Sweetnam
Jul 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I T Young
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Sep 15, 1988·The American Journal of Cardiology·S P Glasser, T W West
Dec 31, 1987·The New England Journal of Medicine·H A Payne
Aug 1, 1984·American Journal of Hematology·S P LevineL K Knieriem
Aug 1, 1981·The American Journal of Cardiology·J Mehta, P Mehta
Jul 1, 1980·Prostaglandins and Medicine·G H RaoJ G White
Dec 1, 1980·Circulation·P C Elwood, P M Sweetnam
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P HjemdahlA H Goodall
May 1, 1993·British Journal of Haematology·D Del PrincipeG Papa
Feb 1, 1994·Circulation·L L-LacosteD Waters
Oct 1, 1993·Circulation·A S KestinA D Michelson
Aug 1, 1995·European Heart Journal·P Hjemdahl
Feb 14, 1998·Journal of the American College of Cardiology·M I FurmanA D Michelson
Mar 6, 1998·International Journal of Cardiology·J D Folts

Related Concepts

Angina Pectoris
Calcium
Calcium Channel Blockers
Double-Blind Method
Cardiopulmonary Exercise Test
Flow Cytometry
Exercise, Isometric
Platelet Activation
Amlodipine, (S)-Isomer, Maleate (1: 1)
Spearman Rank Correlation Coefficient

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.