Effect of amlodipine on left ventricular mass in the Amlodipine Cardiovascular Community Trial

Journal of Cardiovascular Pharmacology
R A KlonerM Wein

Abstract

As part of the Amlodipine Cardiovascular Community Trial (ACCT), which was a large multicenter study designed to assess the effects of the calcium channel blocker amlodipine besylate (Norvasc) as monotherapy for treatment of mild to moderate hypertension, we sought to determine the effects of amlodipine on regression of left ventricular (LV) hypertrophy (LVH). The study began with a 2-week placebo run-in period (baseline), before which antihypertensive drugs had been discontinued. Amlodipine was then administered at 5-10 mg/day during a 4-week titration/efficacy period. Patients achieving a goal diastolic blood pressure (DBP) of < or = 90 mm Hg or a decrease in DBP of > or = 10 mm Hg entered a 12-week maintenance phase and had the option to continue long-term therapy thereafter. Echocardiograms were obtained in a subset of patients at the end of the baseline period. In patients with LVH at baseline, echocardiograms were repeated at the end of 16 weeks of therapy (week 18), and at 42 weeks in patients continuing long-term therapy. Thirty-seven percent of 124 hypertensive patients screened for LVH at baseline had LVH detected on echocardiograms. Blacks had a higher incidence of LVH (64%) as compared with whites (34%, p < 0.05). P...Continue Reading

Citations

Feb 24, 2001·Clinical Cardiology·D Tzivoni
Jan 1, 1997·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·J TangC Wu
May 22, 1997·The American Journal of Cardiology·L Michalewicz, F H Messerli
Aug 29, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·M E Safar, J Blacher
Mar 29, 2008·American Journal of Hypertension·Cesare CuspidiGiuseppe Mancia
Mar 4, 2021·Pharmacological Reviews·Franck Mauvais-JarvisJoshua B Rubin

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