PMID: 2119683Jul 1, 1990Paper

Effect of ammonium-chloride-induced metabolic acidosis on renal electrolyte handling in human neonates

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
E Sulyok, J P Guignard

Abstract

The present study was undertaken to determine the relative contribution of altered glomerular and tubular functions to the metabolic-acidosis-induced increase of renal electrolyte excretion in healthy preterm and full-term neonates and in older infants. Studies were performed in 10 premature infants (mean birth weight 1618 g, gestational age 30.8 weeks) weekly for 6 consecutive weeks, in 11 full-term neonates (mean birth weight 3085 g, gestational age 38.6 weeks) on the 7th day of life and in 25 older control infants (mean age 6.5 months, body weight 6802 g), before and after NH4Cl loading. Blood acid-base parameters, plasma and urine electrolyte and creatinine concentrations were measured, endogenous creatinine clearance and fractional electrolyte excretion (FE) calculated. It was demonstrated that the significant reduction in blood pH and total CO2 content induced by NH4Cl administration was associated with significant increases in glomerular filtration rate (GFR), urine flow rate, FENa and FECl, in each group studied, irrespective of maturity, postnatal age or pre load values. FEK also tended to increase, but the change reached statistical significance only in older infants and in premature babies during the 1st, 2nd and 5th...Continue Reading

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Citations

Mar 1, 2011·Metabolic Syndrome and Related Disorders·Gema SoutoMaria M Adeva
Apr 13, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·María M Adeva, Gema Souto
Jul 3, 2013·The Veterinary Clinics of North America. Food Animal Practice·Ian J LeanPeter J Degaris
Sep 15, 2005·Evolutionary Computation·Ying-ping Chen, David E Goldberg
Jul 24, 2010·Evolutionary Computation·Chung-Yao Chuang, Ying-ping Chen

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