PMID: 11909846Mar 23, 2002Paper

Effect of amoxicillin and co-amoxiclav on the aerobic and anaerobic nasopharyngeal flora

The Journal of Antimicrobial Chemotherapy
I Brook, A E Gober

Abstract

The effects of co-amoxiclav (AMC) and amoxicillin (AMX) therapy on the nasopharyngeal flora of children with acute otitis media (AOM) were compared. Nasopharyngeal culture for aerobic and anaerobic bacteria were obtained before therapy and 2-4 days after completion of antimicrobial therapy in 25 patients treated with either antibiotic. After therapy, 16 (64%) of the 25 patients treated with AMX and 23 (92%) of the 25 patients treated with AMC were considered clinically cured. Polymicrobial aerobic-anaerobic flora were present in all instances. A significant reduction in the number of both aerobic and anaerobic isolates occurred after therapy in those treated with AMX (177 isolates versus 133, P< 0.005) and AMC (172 isolates versus 60, P< 0.001). However, the number of all isolates recovered after therapy in those treated with AMC was significantly lower (60 isolates) than in those treated with AMX (133 isolates, P < 0.001). The recovery of known aerobic pathogens (e.g. Streptococcus pneumoniae, Staphylococcus aureus, beta-haemolytic streptococci, Haemophilus species and Moraxella catarrhalis) and penicillin-resistant bacteria after therapy was lower in the AMC group than in the AMX group (P < 0.005). This study illustrates the ...Continue Reading

References

Aug 1, 1991·The Annals of Otology, Rhinology, and Laryngology·H FadenP L Ogra
Apr 1, 1989·The Annals of Otology, Rhinology, and Laryngology·I Brook, P Yocum
Jun 14, 2000·The Laryngoscope·I BrookW Jackson

❮ Previous
Next ❯

Citations

Feb 11, 2011·Current Infectious Disease Reports·Itzhak Brook
Mar 22, 2005·International Immunopharmacology·Vinciane DufourDominique Meillet
Dec 17, 2009·BMC Infectious Diseases·Itzhak Brook
May 4, 2013·North American Journal of Medical Sciences·Aroor RajeshwaryVidya Pai
Nov 17, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Masatoshi KonnoKimiko Ubukata
Sep 10, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·I Brook
Aug 10, 2012·Journal of Korean Medical Science·Hyo-Jeong Lee Korean Otologic Society
Mar 17, 2007·Scandinavian Journal of Infectious Diseases·Delphine CroisierPascal Chavanet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.