Effect of amoxicillin/clavulanate on gastrointestinal motility in children

Journal of Pediatric Gastroenterology and Nutrition
Roberto GomezCarlo Di Lorenzo

Abstract

The aim of the present study was to evaluate the effect of amoxicillin/clavulanate (A/C) on gastrointestinal motility. Twenty consecutive pediatric patients referred for antroduodenal manometry received 20 mg/kg of A/C into the small bowel lumen. In 10 patients (group A), A/C was given 1 hour after and in 10 (group B), 1 hour before ingestion of a meal. Characteristics of the migrating motor complex, including presence, frequency, amplitude, and propagation of duodenal phase III and phase I duration and phase II motility index (MI), were evaluated 30 minutes before and after A/C administration. There were no statistically significant differences in age and sex between the 2 groups. Manometry studies were considered normal in 8 patients in each group. In group A, 2 patients developed duodenal phase III after receiving A/C, and no significant difference was found in the MI before and after the drug administration. In group B, 9 patients developed duodenal phase III (P <0.05 vs group A). All phase III occurred within a few minutes from the medication administration. Most duodenal phase III contractions were preceded by an antral component during fasting but never after the medication was administered in either of the 2 groups (P<0...Continue Reading

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Citations

Mar 29, 2014·Expert Opinion on Emerging Drugs·William L Hasler
Apr 19, 2016·Best Practice & Research. Clinical Gastroenterology·E G NeelisE H H M Rings
Sep 30, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G Di NardoR De Giorgio
Nov 17, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G Di NardoR De Giorgio
Nov 28, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R RosenS Nurko
Dec 12, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Ricardo A ArbizuLeonel Rodriguez
Apr 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·Steven L CicioraCheryl E Gariepy
Dec 19, 2019·Current Gastroenterology Reports·Heidi E Gamboa, Manu Sood
Jul 25, 2018·Children·Nisha Mangalat, Jeffrey Teckman
Mar 22, 2019·BMC Pediatrics·Giulia GortaniEgidio Barbi
Jul 14, 2020·Current Opinion in Infectious Diseases·Nicholas A TurnerChristopher R Polage
Dec 20, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Katja KovacicMiguel Saps
Feb 20, 2020·Current Opinion in Gastroenterology·Letizia ZenzeriGiovanni Di Nardo
Nov 21, 2020·Pediatric Gastroenterology, Hepatology & Nutrition·Fabrizio ChiusoloAntonella Diamanti
Dec 22, 2020·World Journal of Clinical Cases·Chang-Zhen ZhuYuan-Xin Li
Mar 16, 2021·Terapevticheskiĭ arkhiv·A I ParfenovO V Ahmadullina

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