PMID: 2106131Jan 1, 1990Paper

Effect of amperozide on the synthesis and turnover of monoamines in rat brain

Pharmacology & Toxicology
G PetterssonJ A Engel

Abstract

The effects of amperozide on the synthesis and the turnover of monoamines in different brain regions of the rat were determined using both ex vivo and in vivo biochemical techniques (i.e. post-mortem measurements of the tissue levels by HPLC-EC, and direct measurements with the in vivo voltammetry technique). It was found that amperozide slightly increased the DOPA accumulation and the DOPAC content in limbic brain areas but not in the striatum. The DOPA accumulation was also slightly increased in the noradrenaline rich cortical region indicating increased synthesis of noradrenaline. Furthermore, amperozide increased the utilization of noradrenaline after tyrosine hydroxylase inhibition by alpha-methyl-p-tyrosine. The synthesis of 5-HT was not significantly altered by amperozide. In conclusion, the biochemical data obtained in this study suggest that amperozide produces preferential effects on the mesolimbic dopaminergic system. In addition, amperozide also interacts with the noradrenergic system.

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Citations

Apr 21, 1994·European Journal of Pharmacology·C S TungT H Yin
Jan 1, 1993·Pharmacology, Biochemistry, and Behavior·K KimuraT H Svensson
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·B A McMillenR D Myers
Feb 1, 1995·Schizophrenia Research·A Breier
Oct 8, 1999·Behavioural Brain Research·D J RademacherR E Steinpreis
Sep 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G G NomikosT H Svensson
Jan 1, 1990·Pharmacology & Toxicology·E Christensson, A Björk
Jan 1, 1990·Pharmacology & Toxicology·J Svartengren, P Simonsson
Jan 1, 1990·Pharmacology & Toxicology·E G Christensson
Jan 1, 1990·Pharmacology & Toxicology·B Gustafsson, E Christensson
Jun 1, 1990·Journal of Neuroscience Research·J G NoronhaS I Rapoport

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