PMID: 3384099Jun 20, 1988Paper

Effect of amrinone on myocardial mitochondria function

FEBS Letters
V Bobyleva-GuarrieroG Mattioli

Abstract

The effect of amrinone on cardiac mitochondria of guinea pig was studied. It was found that amrinone does not change the respiratory function of cardiac mitochondria in the presence of alpha-ketoglutarate, whereas it inhibits glutamate oxidation. It was also found that amrinone strongly inhibits the activity of glutamic dehydrogenase of both crude extract from sonicated heart mitochondria and of purified preparation from bovine liver. This inhibition may explain the effect of amrinone on the oxidation of glutamate in mitochondria. These results are discussed in view of the contradictory effects of amrinone on cardiac and other tissues.

References

Apr 3, 1978·Life Sciences·A E Farah, A A Alousi
Mar 1, 1985·Annals of Internal Medicine·J A Franciosa
Jan 1, 1966·Advances in Enzyme Regulation·N KatunumaY Nishii
Jun 18, 1968·Biochimica Et Biophysica Acta·D G GlitzH Fraenkel-Contrat

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Citations

Jan 16, 1989·Biochemical and Biophysical Research Communications·M BelleiV Bobyleva-Guarriero

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