Effect of an acute oral protein load on renal acidification in healthy humans and in patients with chronic renal failure.

Journal of the American Society of Nephrology : JASN
N G De SantoA D'Angelo

Abstract

The effect of a meat load on the renal handling of acid-base balance was studied in ten healthy subjects (GFR by inulin clearance = 98.5 +/- 8.14 ml.min-1.1.73 m-2) and in ten patients affected by chronic renal failure (CRF) (GFR = 39.9 +/- 5.3 ml.min-1.1.73 m-2). After the meat load (2 g.kg-1 body weight of cooked unsalted red meat), GFR increased by 26.9% (peak value) over baseline in healthy subjects and by 32% in CRF patients. The acid-base status of the healthy subjects was in the normal range, whereas the CRF patients disclosed a slight metabolic acidosis. After a meat load, there was, in the healthy subjects, an increase in the filtered load of bicarbonate coupled to an enhanced tubular reabsorption and urinary excretion. The time course between bicarbonate load and urinary excretion was coincident. In CRF patients, the increase of bicarbonate tubular load after the meal was associated with an increase in tubular reabsorption but not in urinary excretion of this anion. The relationship between bicarbonate load and reabsorption was linear in both groups up to the highest filtered loads. Baseline titratable acidity (TA) and ammonium (NH4+) excretion (expressed per ml GFR) were increased in CRF patients as compared with con...Continue Reading

Citations

Jul 28, 2001·Kidney International·P AnastasioN G De Santo
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeffrey A Kraut, Ira Kurtz
Feb 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sukanta BaraiBatchu Suneetha
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P AnastasioN Gaspare De Santo
Sep 10, 2021·Open Heart·James J DiNicolantonio, James H O'Keefe
Mar 1, 2011·Metabolic Syndrome and Related Disorders·Gema SoutoMaria M Adeva
Apr 13, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·María M Adeva, Gema Souto

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