PMID: 8962712Nov 1, 1995Paper

Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats

Experimental Physiology
N HottaH Kakuta

Abstract

To determine the effect of an aldose reductase inhibitor, SNK-860, on the worsening of the electroretinogram (ERG) during a diabetic state, rats with streptozotocin-induced diabetes were administered SNK-860 (1 or 4 mg kg-1 orally) daily for 4 weeks. The effectiveness of SNK-860 in prolonging the peak latencies of oscillatory potentials in the b-wave of the electroretinogram of diabetic rats varied between these different waveform components (designated O1, O2 and O3). SNK-860 (4 mg kg-1 day-1) either completely or partially prevented the prolonged peak latencies at O1 and sigma(O1 + O2 + O3). The drug failed to shorten the latency of the O2 and O3 components, and produced only a modest reduction in retinal levels of sorbitol and fructose, with no increase in myo-inositol. There was a significant correlation between the state of the ERG (components O1 and sigma(O1 + O2 + O3)) and the retinal levels of sorbitol and fructose (P < 0.01), but not of myo-inositol. It is concluded that a better understanding of the mechanism by which SNK-860 acts may provide new insight into the pathogenesis of hyperglycaemic retinal dysfunction and help to establish effective therapy for diabetic retinopathy.

Citations

Dec 20, 2012·PloS One·Peter F KadorKaren Blessing
May 19, 2007·Diagnostic Microbiology and Infectious Disease·Ahmet UrsavaşR Oktay Gözü
Oct 7, 2015·The Journal of Biological Chemistry·Sandra SuarezJohn S Penn
Mar 18, 2003·Diabetes Research and Clinical Practice·Kazuma MiwaNigishi Hotta

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