PMID: 3744171Jun 1, 1986Paper

Effect of an antihypertensive drug, budralazine, on the cerebral circulation in spontaneously hypertensive rats

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
S TanakaA Akashi

Abstract

Budralazine was evaluated for its effect on the cerebral blood flow (CBF) in comparison with some antihypertensive drugs in spontaneously hypertensive rats (SHR). The oral doses for each drug were selected to reduce arterial blood pressure to near normotensive levels. Equihypotensive rats were also produced by a controlled-hemorrhage and used as a control group. The blood flows in the parietal cortex and caudate nucleus were measured using the hydrogen clearance method at the time points when the pressure levels averaged about 120 mmHg after administration of each of the drugs or controlled-hemorrhage. Budralazine (40 mg/kg) significantly increased the regional CBF by approximately 60% with a significant decrease in the cerebral vascular resistance. A similar effect was also observed with hydralazine (9 mg/kg). The CBF-increasing effect of nifedipine (7 mg/kg) was less potent than that of budralazine. Neither prazosin (6 mg/kg) nor alpha-methyldopa (1,000 mg/kg) increased the regional CBF. Such cerebrovascular responses were also observed with controlled-hemorrhage. Furthermore, budralazine given intravenously (3-10 mg/kg) caused a significant and dose-dependent increase (50-250%) in the regional CBF without affecting the arter...Continue Reading

Citations

Feb 22, 2001·Neurobiology of Aging·E FarkasP G Luiten
Apr 20, 2001·Progress in Neurobiology·E Farkas, P G Luiten

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