PMID: 9426346Jan 14, 1998Paper

Effect of an encapsulated anti-elastase compound on experimental gingival inflammation in the rat

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
F GuessousM Roch-Arveiller

Abstract

An animal (rat) model of gingival injury ("impaction") induced a gingival inflammatory reaction, which was characterized by a breakdown of gingival collagen and the elastic network, as well as a significant increase of gingival elastase. The present study was conducted to investigate whether ceramides, sphingolipids composed of sphingosine N-acyl-linked to fatty acids, a chemical structure with antielastase properties, could counteract the development of such an inflammatory process. The ceramides used in these experimental series were extracted from wheat and characterized. The main fatty acids were 16:0, 18:1, 18:2, and the sphingoid moiety was phytosphingosine. Inhibition of elastase by ceramides was demonstrated in vitro and the concentration necessary to inhibit 50% of elastase activity was 41 mg/l using the synthetic substrate methoxysuccinyl-alanine-alanine-proline-valine-p-nitroanilide (MeOSuc-AlaAlaProValpNA). However, this anti-elastase activity was not observed in vivo in our animal model of gingival inflammation. A glycosaminoglycan (Heparin), recognized as a potent inhibitor of elastase, was entrapped in ceramides. A local treatment of impacted gingivae by encapsulated heparin led to a dose-related decrease of the ...Continue Reading

References

Mar 7, 1977·Biochemical and Biophysical Research Communications·B M Ashe, M Zimmerman
Apr 1, 1992·International Journal of Biological Macromolecules·S LegrasM Moczar
Sep 1, 1992·Journal of Periodontal Research·Y T TengC A McCulloch
Apr 1, 1992·Journal of Periodontology·K G PalcanisM K Jeffcoat
Sep 1, 1991·Clinical Science·R L WalshG McLennan
Aug 1, 1991·International Journal of Biological Macromolecules·E Moczar, W Hornebeck
Jan 1, 1991·Journal of Periodontal Research·G G ZafiropoulosD N Tatakis
Aug 1, 1990·The American Review of Respiratory Disease·N V RaoJ R Hoidal
Jul 1, 1990·The Journal of Pharmacy and Pharmacology·E O AdeyemiH J Hodgson
Oct 23, 1990·Biochemistry·S C Tyagi, S R Simon
Nov 1, 1982·Journal of Clinical Periodontology·J M GoodsonS S Socransky
Nov 1, 1994·Journal of Pharmacological and Toxicological Methods·F GuessousM Roch-Arveiller
Feb 1, 1994·Journal of Periodontology·G C ArmitageT J Sharp
Jan 1, 1993·Journal of Clinical Periodontology·E AdonogianakiD F Kinane
Sep 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·C RegnaultG Hazebroucq
Dec 1, 1995·International Journal of Cosmetic Science·V Bizot-FoulonW Hornebeck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.