PMID: 6402036Feb 22, 1983Paper

Effect of an exogenous energy source and amino acids on DNA synthesis in regenerating rat liver

Biochimica Et Biophysica Acta
T ChibaS Fujii

Abstract

Rats on a protein-free diet synthesized less DNA after partial hepatectomy than rats on a normal diet. In regenerating livers of animals on the protein-free diet, induction of several enzymes involved in the DNA precursor synthetic pathway, and especially ribonucleotide reductase, were depressed. When young rats were maintained solely by parenteral nutrition after partial hepatectomy, exogenous amino acids were more important than the exogenous energy source for induction of enzymes involved in synthesis of DNA and its pyrimidine nucleotide precursors. In particular, induction of ribonucleotide reductase appeared to be controlled by exogenous amino acids. Tryptophan, methionine, phenylalanine, leucine, valine, isoleucine and threonine seemed to stimulate the induction of this enzyme most after partial hepatectomy.

References

Jul 10, 1979·Biochemistry·Y EngströmM Akerman
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Citations

Mar 17, 1999·Annals of Surgery·S T FanJ Wong
Dec 11, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yunsheng YuanYan Yu
Jan 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·P RigottiJ E Fischer
Jul 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·G K Grimble, D B Silk
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T L FreemanM E Mailliard
Jan 25, 2008·Annals of Surgery·Namir Katkhouda
Apr 1, 1997·Journal of Gastroenterology and Hepatology·S T Fan
Jun 11, 2002·Archives of Biochemistry and Biophysics·Thomas L FreemanMark E Mailliard
May 7, 1993·Biochimica Et Biophysica Acta·M LorenziR Pagani
Nov 6, 1987·Biochimica Et Biophysica Acta·A TabucchiE Marinello
Sep 1, 1990·The Journal of Surgical Research·K A CampbellJ V Sitzmann

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