PMID: 42873Oct 1, 1979

Effect of an increase in HbO2 affinity on the calculated capillary recruitment of an isolated rat heart

Pflügers Archiv : European journal of physiology
J L MartinM Duruble

Abstract

The effect of an increase in hemoglobin O2 affinity on myocardial O2 delivery was studied in a blood perfused working rat heart preparation. In a first series of experiments P50 (PO2 for which saturation is 50%) was lowered by use of carbon monoxide. The heart was alternatively perfused with the blood sample of P50 = 32 mm Hg and the blood sample of P50 = 17 mm Hg. O2 capacity of both samples was kept the same by appropriate hemodilution. In a second serie of experiments change of P50 was obtained by the use of adult human erythrocytes containing hemoglobin creteil with a P50 of 13.6 mm Hg. As P50 decreased from 25 to 10 mm Hg, coronary sinus PO2 (PcsO2) diminished from 26 +/- 2 to 18 +/- 2 mm Hg (-29 +/- 2%), coronary sinus O2 content (CcsO2) increased by 15 +/- 3%, myocardial oxygen consumption did not change significantly. The percentage of increase of coronary flow was 23 +/- 4%. Analysis of these results with a simple mathematical model of O2 delivery suggest that increase in HbO2 affinity is corrected by a simultaneous increase in coronary flow and capillary recruitment.

References

May 1, 1976·The Journal of Surgical Research·T OrellanoK B Absolon
Oct 1, 1976·Journal of Applied Physiology·M DuvelleroyM Cain
May 1, 1975·Journal of Applied Physiology·E O YhapE C Alix
Feb 1, 1970·Journal of Applied Physiology·M A DuvelleroyM B Laver

Citations

Dec 1, 1984·Respiration Physiology·B P TeisseireD N Laurent
Feb 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·O Irtun, D Sørlie
Sep 15, 2006·Critical Care : the Official Journal of the Critical Care Forum·Marc BuiseDiederik Gommers
Jan 1, 1983·Respiration Physiology·C D SoulardR A Herigault

Related Concepts

Blood Capillaries
Coronary Circulation
Abnormal Hemoglobins
Hydrogen-Ion Concentration
Myocardium
Oxygen Consumption
Oxyhemoglobin

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