PMID: 15243316Jul 10, 2004Paper

Effect of an oral bulking agent and a rectal laxative administered alone or in combination for the treatment of constipation

Gastroentérologie Clinique Et Biologique
Michel BouchouchaMichel Arsac

Abstract

The aim of the present study was to search for a synergetic action between psyllium and a defecation-inducing drug, Eductyl, for symptom relief in patients suffering from chronic constipation. Twenty healthy volunteers and 20 patients complaining of chronic constipation were included in a randomized crossover study. The study was divided into four 2-weeks periods: pre-inclusion and three periods of treatment with psyllium, Eductyl, and Eductyl + psyllium respectively. Colonic transit time was determined at the end of each period of treatment. During each of the four periods, a self-administered questionnaire was used to assess symptoms of constipation. For constipated patients, treatment with Eductyl and Eductyl-psyllium improved clinical symptoms of constipation: increased stool frequency, resulted in fewer hard stools and less sensation of incomplete evacuation and less straining to defecate. The improvement was associated with a decrease in total and segmental colonic transit time. The Eductyl-psyllium combination did not exhibit any synergetic effect. Treatment with Eductyl alone is more efficient than with psyllium alone in providing symptom relief. Combination with psyllium is not synergetic.

References

Aug 1, 1992·Diseases of the Colon and Rectum·M BouchouchaJ P Barbier
Jun 1, 1991·Baillière's Clinical Gastroenterology·M Karaus, M Wienbeck
Jul 1, 1994·Journal of Clinical Gastroenterology·K W Heaton, L J O'Donnell
Sep 1, 1994·Digestive Diseases and Sciences·G BassottiW E Whitehead
Apr 1, 1993·Diabetes·F Q Nuttall
Jul 1, 1996·Gut·L P Degen, S F Phillips
Aug 1, 1997·Diseases of the Colon and Rectum·A KochS Müller-Lissner
Jul 15, 1998·Alimentary Pharmacology & Therapeutics·J W McRorieM Robinson
Aug 24, 1999·Gut·W G ThompsonS A Müller-Lissner
Aug 24, 1999·Gut·W E WhiteheadS S Rao
Aug 24, 1999·Gut·S J Veldhuyzen van ZantenA R Zinsmeister
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Bouchoucha, S R Thomas
Jun 8, 2001·Gastroenterology Clinics of North America·A E Bharucha, S F Phillips
Jul 27, 2001·Current Treatment Options in Gastroenterology·Adil E. Bharucha, Sidney F. Philips
May 2, 2002·Journal of Gastroenterology and Hepatology·Ahmed Shafik, Ismail Ahmed
Oct 2, 2002·International Journal of Colorectal Disease·Michel BouchouchaMichel Arsac

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Citations

Feb 13, 2008·PLoS Computational Biology·Arend Hintze, Christoph Adami
Jun 15, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Anne Laure TarreriasPhilippe Ducrotté
Jul 23, 2011·Techniques in Coloproctology·F PuccianiM N Ringressi
Aug 28, 2012·Expert Opinion on Drug Metabolism & Toxicology·Nelida FernandezMatilde Sierra
Sep 1, 2015·BMC Complementary and Alternative Medicine·Ana M SahagúnMatilde Sierra
Apr 3, 2013·The American Journal of Gastroenterology·Shanti EswaranWilliam D Chey
Apr 3, 2019·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·A Chiarugi, A Camaioni
Jul 22, 2017·International Journal of Molecular Medicine·Magdy El-SalhyDoris Gundersen
Mar 27, 2021·The American Journal of Gastroenterology·Satish S C Rao, Darren M Brenner

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