Effect of an oral contraceptive in primary dysmenorrhea--changes in uterine activity and reactivity to agonists

Contraception
P EkströmM Akerlund

Abstract

Mechanisms for the therapeutic effect of oral contraceptives in dysmenorrhea were studied by recording intrauterine pressure on the first day of menstrual bleeding in women with moderate to severe symptoms and after three weeks of oral contraceptive therapy (150 micrograms levonorgestrel + 30 micrograms ethinyl estradiol, daily). Spontaneous uterine activity and reactivity to intravenous injections of vasopressin (6 pmol/kg body weight; n = 8) or prostaglandin F2 alpha (12 nmol/kg body weight; n = 9) at the two sessions were compared. During the first recording when all women had dysmenorrhea, the uterine activity and reactivity to both agonists were pronounced. After therapy, when the women felt essentially no pain, a statistically significant decrease in spontaneous uterine activity in terms of total pressure area, frequency and amplitude of contractions was observed. The agonist injections induced less pain at the second recording, although the magnitude of responses, superimposed on the much smaller uterine activity at this time, were not significantly different from those at the first recording during dysmenorrhea. The mechanism of pain relief by oral contraception in dysmenorrhea could be a lesser impact of the decreased ...Continue Reading

References

Aug 1, 1979·British Journal of Obstetrics and Gynaecology·O YlikorkalaA Kauppila
Sep 1, 1977·Prostaglandins·S ShaalaM Toppozada
Jan 1, 1970·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·L P Bengtsson
Jul 26, 1947·Journal of the American Medical Association·R A WOODBURY, R TORPIN

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Citations

Dec 25, 2002·Contraception·Susan L Hendrix, Nancy J Alexander
Sep 1, 2000·Journal of Ethnopharmacology·H O VongtauC Wambebe
Feb 1, 1996·The Journal of the American Association of Gynecologic Laparoscopists·A J DulebaD L Olive
May 19, 2001·Journal of Pediatric and Adolescent Gynecology·A R Davis, C L Westhoff
Nov 1, 1995·British Journal of Obstetrics and Gynaecology·T BossmarM Maggi
Dec 19, 2006·Journal of Pediatric and Adolescent Gynecology·Zeev Harel
Jun 25, 2008·Annals of the New York Academy of Sciences·Zeev Harel
Nov 15, 2002·Paediatric Drugs·Zeev Harel
Feb 13, 2016·Reproductive Medicine and Biology·Aki Kido, Kaori Togashi
Dec 13, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Piotr PierzyńskiTadeusz Laudański

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