Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis.

Tuberculosis Research and Treatment
Eduard BaqueroFernando Echeverri

Abstract

Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.

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Citations

Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhamad Harith MazlunZunoliza Abdullah
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kinga ParuchMonika Wujec
Sep 18, 2021·Phytotherapy Research : PTR·Fahimeh NourbakhshVahid Soheili

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Methods Mentioned

BETA
transmission electronic microscopy
column chromatography
light microscopy

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