Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients - a randomized controlled trial: study protocol

BMC Psychiatry
Manuel FöckerLars Libuda

Abstract

Depression is a significant health and economic burden worldwide affecting not only adults but also children and adolescents. Current treatment options for this group are scarce and show moderate effect sizes. There is emerging evidence that dietary patterns and specific nutritional components might play a role in the risk for developing depression. This study protocol focusses on the role of vitamin D which is for long known to be relevant for calcium and phosphorous homeostasis and bone health but might also impact on mental health. However, the assessment of the vitamin D status of depressed juvenile patients, or supplementation of vitamin D is currently not part of routine treatment. Controlled intervention studies are indispensable to prove whether a vitamin D deficiency ameliorates depressive symptoms. This double blinded, randomized controlled trial will enroll 200 inpatients from a child and adolescent psychiatric department with a vitamin D deficiency defined by a 25(OH)-vitamin D-level < 30 nmol/l (12 ng/ml) and a Beck Depressions Inventory (BDI-II) score > 13 (indicating at least: mild depression). Upon referral, all patients will be screened, checked for inclusion criteria, and those eligible will be randomized afte...Continue Reading

References

Aug 1, 1986·Clinics in Endocrinology and Metabolism·J M Tanner
Mar 13, 2001·The American Psychologist·R A Thompson, C A Nelson
Mar 15, 2002·Trends in Endocrinology and Metabolism : TEM·Emmanuel GarcionDidier Wion
Oct 5, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Graham J EmslieJennie G Jacobson
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Jun 23, 2004·Preventive Medicine·William S Harris, Clemens Von Schacky
Aug 21, 2004·Journal of Child and Adolescent Psychopharmacology·Kirsi-Maria Haapasalo-PesuMauri Marttunen
Apr 22, 2006·BMJ : British Medical Journal·Jo C DumvilleCatherine E Hewitt
Mar 9, 2007·The American Journal of Clinical Nutrition·Reinhold ViethArmin Zittermann
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Oct 9, 2007·Medical Hypotheses·John Jacob Cannell
Dec 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joyce C McCann, Bruce N Ames
Apr 11, 2008·The American Journal of Clinical Nutrition·Catherine A McCarty
May 7, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Thomas Kliche, R Mann
Feb 24, 2009·Public Health Nutrition·Anna StahlGert B M Mensink
Mar 12, 2009·Psychopathology·Manfred DöpfnerUNKNOWN German CBCL Study Group
May 8, 2009·The American Journal of Clinical Nutrition·Katalin FeketeTamás Decsi
May 30, 2009·Public Health Nutrition·Petra StieglerJoachim Heinrich
Jun 10, 2009·Journal of Affective Disorders·Kaeleen DingleAlexandra Clavarino
Mar 5, 2010·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Monika DasekingHans-Christian Waldmann
Mar 11, 2010·The Journal of Steroid Biochemistry and Molecular Biology·J Wesley PikePaul D Goetsch
Apr 20, 2010·The Australian and New Zealand Journal of Psychiatry·Felice N JackaJoanne W Williams
Apr 27, 2010·Human Molecular Genetics·Jiyoung AhnDemetrius Albanes
Dec 15, 2010·Journal of Science and Medicine in Sport·F N JackaM Berk
Feb 1, 2009·Journal of Evidence-based Medicine·Hanna HasselblattMartin Schumacher
Mar 30, 2011·Journal of the American Dietetic Association·A Catharine RossSue A Shapses
Oct 14, 2011·European Archives of Psychiatry and Clinical Neuroscience·H Y JaddouK M Ajlouni
Jan 14, 2012·Progress in Histochemistry and Cytochemistry·Walter E Stumpf
Jan 27, 2012·The Journal of Clinical Endocrinology and Metabolism·Anna-Maija TolppanenDebbie A Lawlor
Apr 3, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J V PottalaW S Harris
Jun 26, 2012·European Journal of Nutrition·Elske M Brouwer-BrolsmaLisette C P G M de Groot
Dec 12, 2012·Journal of Psychopharmacology·Colin HendrieEmma Robinson
Jan 5, 2013·BMC Medicine·Almudena Sanchez-Villegas, Miguel A Martínez-González
Apr 10, 2013·Molecular Psychiatry·Y MilaneschiB W J H Penninx

❮ Previous
Next ❯

Citations

Apr 25, 2020·European Journal of Nutrition·Prem R ShakyaTiffany K Gill
Dec 15, 2020·Current Treatment Options in Psychiatry·Kathryn R CullenBonnie Klimes-Dougan
Apr 8, 2021·BMC Psychiatry·Roland MerglChristian Sander
Jun 12, 2021·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Lars LibudaAnke Hinney
Aug 17, 2021·Medicine·Laila M SheriefWesam A Mokhtar

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.