PMID: 6133837Jun 1, 1983

Effect of anaerobic bacteria on killing of Proteus mirabilis by human polymorphonuclear leukocytes

Infection and Immunity
F NamavarD M MacLaren

Abstract

Killing of Proteus mirabilis by human polymorphonuclear leukocytes was tested in the presence of different Bacteroides species. In vitro experiments showed that anaerobic bacteria interfered with the killing of aerobic bacteria. However, this inhibitory effect was not a property of all Bacteroides species. Bacteroides gingivalis W83 showed the greatest inhibitory effect of the five Bacteroides strains tested. Killing of P. mirabilis was inhibited by the culture supernatant of B. gingivalis but not by washed cells. Two factors were found in the supernatant of B. gingivalis to account for the inhibitory effect. One was heat stable with a molecular weight of less than 3,500 and inhibited the killing activity of leukocytes, and the other was heat labile and partly inactivated the complement system. The killing experiments paralleled chemiluminescence measurements.

Citations

Mar 1, 1990·World Journal of Surgery·T Hau
Jan 1, 1984·Antonie van Leeuwenhoek·D M MacLarenJ A Kaan
Jan 1, 1994·FEMS Microbiology Reviews·I Brook
Mar 1, 1988·Journal of Clinical Periodontology·A J van WinkelhoffJ de Graaff
Jan 1, 1985·Journal of Periodontal Research·T J van SteenbergenJ de Graaff
Nov 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S Tabaqchali, M Wilks
Jan 1, 1984·Antonie van Leeuwenhoek·T J van SteenbergenJ de Graaff
Aug 1, 1985·Journal of Clinical Pathology·J J Finlay-Jones, M Reznikov
Jul 27, 1989·The New England Journal of Medicine·B Styrt, S L Gorbach
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Ioannis P KioumisDavid P Nicolau
Jan 1, 1987·Critical Reviews in Microbiology·I Brook
Feb 1, 1997·FEMS Immunology and Medical Microbiology·K B Abdul-MajidJ J Finlay-Jones

Related Concepts

Bacteroides
Bacteroides fragilis
Prevotella melaninogenica
Blood Bactericidal Activity
Phosphorescent Measurements
Neutrophil Band Cells
Proteus mirabilis

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