Effect of ancillary drugs on sevoflurane related emergence agitation in children undergoing ophthalmic surgery: a Bayesian network meta-analysis

BMC Anesthesiology
Dan TanFuquan Wang

Abstract

The comparative efficacy of ancillary drugs on sevoflurane related emergence agitation (EA) in children undergoing ophthalmic surgery remains controversial. The databases were retrieved in an orderly manner from the dates of their establishment to October, 2018, including PubMed, The Cochrane Library and Web of Science, to collect randomized controlled trials (RCT) of different anesthetic drugs combined with sevoflurane for ophthalmic surgery. Then a network meta-analysis was conducted using R and Stata 12.0 softwares. The meta-analysis showed that, in reducing sevoflurane related EA, dexmedetomidine, ketamine, propofol, fentanyl, midazolam, sufentanil, remifentanil and clonidine were superior to placebo (P < 0.05). The network meta-analysis showed that the effects of ancillary drugs combine with sevoflurane in reducing risk of EA in children undergoing ophthalmic surgery was superior to placebo: dexmedetomidine (OR = 0.17, 95% CrI 0.12-0.22), ketamine (OR = 0.30, 95% CrI 0.11-0.49), propofol (OR = 0.24, 95% CrI 0.09-0.63), fentanyl (OR = 0.16, 95% CrI 0.08-0.56), midazolam (OR = 0.20, 95% CrI 0.09-0.40), sufentanil (OR = 0.27, 95% CrI 0.14-0.41), remifentanil (OR = 0.18, 95% CrI 0.08-0.54) and clonidine (OR = 0.14, 95% CrI 0.0...Continue Reading

References

Jan 1, 1992·International Ophthalmology Clinics·L de SaW V Good
Jan 4, 2001·Journal of Cardiothoracic and Vascular Anesthesia·I R ThomsonR J Hudson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 31, 2009·American Journal of Ophthalmology·Yassine J DaoudTerry Kim
Jul 16, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ayse MizrakUnsal Oner
Mar 15, 2012·Journal of Anesthesia·Xu LiliZhou Haiyan
Jan 25, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jia-Yao ChenWen-Xian Li
Feb 12, 2013·Journal of Pediatric Ophthalmology and Strabismus·Laura J HeinmillerAdam R Thode
Nov 10, 2015·The Journal of Clinical Pediatric Dentistry·A Devasya, M Sarpangala
Nov 26, 2015·Journal of Anesthesia·Akihiro Kanaya
Feb 18, 2016·The Journal of International Medical Research·Kyung Mi KimEunsu Kang
Jan 10, 2017·Drug and Alcohol Dependence·Joji Suzuki, Saria El-Haddad
Jan 21, 2017·Clinical Pharmacokinetics·Maud A S WeerinkPieter Colin
Mar 17, 2017·Anesthesia, Essays and Researches·Safiya Imtiaz ShaikhM Marutheesh
Mar 25, 2017·Drugs·Stephan A Schug, Sonya Ting
Oct 3, 2017·The Journal of Emergency Medicine·Kathleen M AdelgaisMarion R Sills
Dec 7, 2017·Indian Journal of Ophthalmology·Sudarshan Kumar KhokharPulak Aggarwal
Oct 4, 2018·European Journal of Ophthalmology·Jean-Baptiste DucloyerPierre Lebranchu

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.