PMID: 7540162Feb 1, 1995Paper

Effect of androgens on the germ cell-depleted testes of prenatally irradiated rats

International Journal of Andrology
G VerhoevenW Heyns

Abstract

To study the effect of androgens on somatic testicular cells, rats were rendered germ cell depleted by prenatal irradiation (RX). Adult RX rats were treated with a desensitizing dose of a GnRH agonist (GnRHa; Zoladex), combined with an antiandrogen (Nilutamide) to preclude all androgen effects, or combined with testosterone or hCG to restore androgen action. The effect of these treatments for 3 weeks on the weight of testes and accessory sex glands, hormones (LH, FSH, testosterone, inhibin), testicular proteins, the pattern of incorporation of [35S]-methionine into testicular proteins (studied by two dimensional gel electrophoresis) and steady state mRNA levels for transferrin and androgen-binding protein (ABP) were evaluated. Combined treatment with GnRHa and antiandrogen virtually eliminated gonadotrophins, androgens and androgen effects. Testicular weight was reduced to 50% of that observed in RX controls. Treatment with GnRHa and testosterone resulted in supraphysiological levels of testosterone and testicular weights comparable to those observed in RX controls. FSH levels in these animals, however, were in the normal range. A low dose of hCG also restored testicular weight in the presence of low concentrations of serum tes...Continue Reading

References

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Citations

Mar 24, 1998·Molecular and Cellular Endocrinology·M EsquenetG Verhoeven
Oct 23, 1998·Molecular and Cellular Endocrinology·L VerlindenR Bouillon
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·J V SwinnenG Verhoeven
Dec 24, 2005·Asian Journal of Andrology·J ErenpreissA Giwercman
Feb 5, 2015·BioMed Research International·Philip J ChanAlbert K Wei
Apr 14, 2016·Reading and Writing·Ludo VerhoevenEliane Segers
Oct 27, 2016·Psychological Reports·Kyoko AsakuraIkue Watanabe

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