Effect of Angelica sinensis polysaccharide-iron complex on iron deficiency anemia in rats

Chinese Journal of Integrative Medicine
Pei-pei WangKai-Ping Wang

Abstract

To investigate the therapeutic effects of Angelica sinensis polysaccharide-iron complex (APIC) on rats with iron deficiency anemia (IDA). The IDA rat model was established by adopting low-iron forage with a small amount of regular bloodletting. The rats were randomly divided into a model group, three AIPC groups (high, middle, and low dosage), an Angelica sinensis polysaccharide (ASP) group, a mixture group (ASP+FeCl(3)) and a positive control group (Niferex). Changes in hemoglobin (Hb), red blood cell count (RBC), hematocrit (HCT) and iron content of whole blood were observed. There was a significant difference before and after administration in all treated groups and all indices were restored to near-normal levels in the APIC groups and the positive control group. There was a significant difference among the changes of the indices in all the APIC groups and those of the model group but not between those of the APIC groups and the positive control group. However, the recovery of the indices in the APIC groups was superior to that in the positive control group. APIC not only has a superior therapeutic effect on IDA, but also has the effect of the ASP on supplementing blood and activating blood circulation. Hence, it may be used...Continue Reading

Citations

Apr 27, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chia-Yen HsiaoKin-Fu Chak
Jun 8, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Haifeng HouWanyu Shi
Feb 22, 2011·Journal of Ethnopharmacology·Kai-Ping WangYu Zhang
May 29, 2018·Mediators of Inflammation·Tarcisio Vitor Augusto LordaniMaria Valdrinez Campana Lonardoni
Mar 7, 2021·International Journal of Molecular Sciences·Coralia CotoraciAnca Hermenean
Apr 13, 2021·International Journal of Pharmaceutics·Riddhi Trivedi, Kalyani Barve
Jun 7, 2021·International Journal of Biological Macromolecules·Jijuan NaiHuagang Sheng

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