PMID: 9180154May 29, 1997Paper

Effect of angiogenesis inhibitor TNP-470 on the progression of human gastric cancer xenotransplanted into nude mice

International Journal of Cancer. Journal International Du Cancer
T KanaiS Baba

Abstract

The effect of an angiogenesis inhibitor, TNP-470, on primary tumor growth, liver metastasis and peritoneal dissemination of gastric cancer was investigated by means of an orthotopic xenotransplanted model of 2 human gastric cancers, MT-2 and MT-5. TNP-470 showed a significant inhibitory effect on the growth of primary tumors after orthotopic transplantation of both xenografts when given at a dose of 30 mg/kg on alternate days from day 7 after transplantation (early treatment). However, growth of the MT-2 primary tumor was not inhibited by administration from day 14 after transplantation (late treatment). Liver metastasis was prevented significantly by early treatment of TNP-470. In particular, early treatment of MT-2 completely inhibited the development of macroscopic foci in the liver and was significantly more effective than late treatment. Peritoneal dissemination also was inhibited. Thus, TNP-470 was revealed to have strong inhibitory activity not only on primary tumors and liver metastases but also against peritoneal dissemination. These results suggest that this agent may provide a new approach to the treatment of gastric cancer.

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Citations

Dec 1, 2001·Expert Opinion on Biological Therapy·T G Zogakis, S K Libutti
Nov 4, 2000·Expert Opinion on Investigational Drugs·E A Kruger, W D Figg
Sep 1, 2010·Expert Opinion on Drug Discovery·Robert M Hoffman
Apr 5, 2008·Critical Reviews in Oncology/hematology·Teresa TroianiFortunato Ciardiello
May 17, 2005·Journal of Surgical Oncology·Howard Silberman
May 18, 2000·Cancer Treatment Reviews·M M EatockS B Kaye
Feb 15, 2001·Japanese Journal of Cancer Research : Gann·H KatoT Yoshiki
Jul 5, 2001·Journal of the National Cancer Institute·A L FeldmanS K Libutti
Nov 11, 1999·Medizinische Klinik·D SchieferA Engert
Sep 25, 2003·Fertility and Sterility·Ying-Fang ZhouShinobu Sakamoto

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