Effect of angiotensin-converting enzyme inhibition on myocardial vascularization in the adolescent and adult spontaneously hypertensive rat

Journal of Hypertension
M Jane BlackC I Johnston

Abstract

To determine whether angiotensin-converting enzyme (ACE) inhibition treatment enhances myocardial vascularization in adolescent and adult spontaneously hypertensive rats (SHRs). Male SHRs were treated from 7 to 14 or from 16 to 24 weeks of age with the ACE inhibitor, perindopril, in either a low dose (0.1 mg/kg per day) or a high dose (1 mg/kg per day). Some rats were concomitantly treated with a bradykinin antagonist. At termination of treatment, the left ventricular wall was extensively sampled and the surface area density and length density of myocardial blood vessels stereologically determined. High-dose perindopril treatment prevented the development of hypertension and left ventricular hypertrophy in adolescent SHRs and markedly reduced blood pressure and left ventricular size in adult SHRs. SHRs treated with the low dose of perindopril remained hypertensive, although there were significant reductions in blood pressure and left ventricular growth. High-dose perindopril treatment in adolescent SHRs led to a significant increase in the surface area density of blood vessels in the left ventricle after 4 weeks of treatment and an increase in both the surface area density and length density of blood vessels after 7 weeks of tr...Continue Reading

References

Feb 1, 1975·Circulation Research·E G Erdös
Sep 1, 1990·Journal of Microscopy·T MattfeldtP Möller
Jul 11, 1988·The American Journal of Cardiology·C D Furberg, S Yusuf
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Feb 1, 1995·The American Journal of Physiology·S P Fauteck, S C Kandarian
Dec 1, 1994·Journal of the American College of Cardiology·M F FlanaganA M Fujii
Jul 1, 1996·Journal of Vascular Research·O Hudlicka, M D Brown
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·M J BlackC I Johnston

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Citations

Mar 4, 2003·Journal of Cellular and Molecular Medicine·R L de Andrade ZorziC A Mandarim-de-Lacerda
May 11, 2005·International Journal of Cardiology·Alfredo de Souza Bomfim, Carlos Alberto Mandarim-de-Lacerda
Mar 20, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jan KlimasSimon W Rabkin
May 29, 2010·American Journal of Hypertension·Haytem DebbabiBernard I Levy

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