PMID: 2107760Mar 1, 1990Paper

Effect of angiotensin II and norepinephrine on isolated rat afferent and efferent arterioles

The American Journal of Physiology
B H YuanJ D Conger

Abstract

Differential sensitivity of the pre- and postglomerular arterial vessels to vasoconstrictor activity of angiotensin II (ANG II) and norepinephrine (NE) is controversial. To avoid the complex extravascular neurohumoral variables that may have accounted for different results in the intact rat kidney, an isolated arteriole technique was used to examine the dose responses of ANG II and NE on afferent (AA) and efferent arterioles (EA) from Sprague-Dawley rats. EA were more sensitive than AA to ANG II (EC50 = 3.2 +/- 1.8 x 10(-11) and 1.0 +/- 1.6 x 10(-9) M, respectively, P less than 0.001), whereas EC50 of both AA and EA to NE were similar (3.4 +/- 2.3 x 10(-8) and 1.4 +/- 2.6 x 10(-8) M, respectively). The dose-response curves of AA to ANG II were not different when perfused at different luminal pressures (90 and 30 mmHg). In contrast, EA were more sensitive to ANG II at 30 than at 90 mmHg (3.0 +/- 1.2 x 10(-11) and 5.0 +/- 1.8 x 10(-10) M, respectively, P less than 0.005). The EC50 of EA to NE was unaffected by similar changes in luminal pressures. The mean dose-response curves of AA to ANG II were the same with and without the addition of 10(-5) M indomethacin; however, in arterioles displaying a focal constriction pattern to ANG...Continue Reading

Citations

Nov 13, 2004·American Journal of Physiology. Renal Physiology·Rachel W FalletPamela K Carmines
Oct 12, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael HultströmA Erik G Persson
Oct 1, 2010·The Keio Journal of Medicine·Koichi HayashiHiroshi Itoh
Jul 14, 2012·American Journal of Physiology. Renal Physiology·Peter VavrinecRichard P E van Dokkum
Oct 11, 2013·American Journal of Physiology. Renal Physiology·Robert Moss, S Randall Thomas
Feb 8, 2000·American Journal of Physiology. Renal Physiology·M SalomonssonW J Arendshorst
Oct 21, 2004·American Journal of Physiology. Renal Physiology·Seiji HashimotoJurgen Schnermann
Jul 27, 2007·American Journal of Physiology. Renal Physiology·Hiroshi IdeuraYoshihisa Nojima
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi NakamotoFumihiko Kajiya
Apr 3, 2009·American Journal of Physiology. Renal Physiology·Erdmann SeeligerBert Flemming
Jun 21, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kenji YoshiokaKenzo Hirao
Nov 14, 2002·American Journal of Physiology. Renal Physiology·Lisa M Harrison-BernardThomas M Coffman
Feb 24, 2001·American Journal of Physiology. Renal Physiology·G J WehbiK D Burns
Oct 26, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andreas PatzakErdmann Seeliger
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pernille B HansenJurgen Schnermann
May 24, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takayasu OhtakeShuzo Kobayashi

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