PMID: 6987895Feb 1, 1980Paper

Effect of angiotensin II and sodium depletion on angiotensinogen production

The American Journal of Physiology
H C HerrmannI A Reid

Abstract

An in vitro preparation of liver slices was used to study the effect of angiotensin II and sodium depletion on the synthesis of angiotensinogen in rats. Two other treatments known to increase plasma angiotensinogen concentration in vivo, viz., intraperitoneal administration of dexamethasone or ethinyl estradiol, resulted in an increase in the rate of release of angiotensinogen by liver slices; this increase was inhibited by adding actinomycin D or vincristine to the incubation medium. Intravenous infusion of angiotensin II (33 ng/min for 3 days) also produced a marked increase in the release of angiotensinogen concentration and a decrease in plasma renin activity. In contrast, no change in the rate of release of angiotensinogen was observed in rats depleted of sodium for 7--14 days, even though these animals exhibited a marked increase in plasma angiotensin II concentration. Plasma angiotensinogen concentration decreased by 30%, presumably as a consequence of the accompanying increase in renin secretion. These results provide further evidence that the synthesis of angiotensinogen may be increased by angiotensin II, but indicate that the circulating level of angiotensin II in sodium-deficient animals is not sufficiently high to ...Continue Reading

References

Mar 7, 1977·Biochemical and Biophysical Research Communications·K WeigandC Falge
Oct 1, 1977·Circulation Research·L R Krakoff, A J Eisenfeld
Oct 11, 1976·The American Journal of Physiology·O BeatyV M Buckalew
Nov 1, 1969·The American Journal of Physiology·A Nasjletti, G M Masson
May 1, 1971·European Journal of Clinical Investigation·E Rosset, R Veyrat
Aug 1, 1972·The American Journal of Physiology·R H Freeman, H H Rostorfer
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·A Nasjletti, G M Masson
Jul 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·E REICH TATUMEL

Citations

Nov 1, 1992·The American Journal of Physiology·H SchunkertV J Dzau

Related Concepts

Angiotensin II, Val(5)-
Renin Substrate Tetradecapeptide
Angiotensins
Ac-De
Oradexon
Estradiol, (16 alpha,17 beta)-Isomer
Liver
Preprorenin
Sodium
Cellcristin

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