PMID: 3121505Dec 1, 1987Paper

Effect of angiotensin II on baroreceptor reflex control of heart rate in conscious baboons

Hypertension
M G GarnerD J Tiller

Abstract

Studies of the baroreceptor-heart rate reflex were performed in four conscious, unrestrained male baboons to determine whether changes in circulating angiotensin II within the physiological range are associated with alterations in baroreceptor reflex sensitivity. With the animals on a high sodium intake, studies were performed before and during graded angiotensin II infusion (10 and 20 ng/kg/min). To separate effects on baroreceptor reflex function mediated by angiotensin II-induced increases in arterial pressure, these studies were repeated on a different day with simultaneous glyceryl trinitrate infusion to prevent increases in pressure during angiotensin II infusion. With the animals on a low sodium intake, studies were performed before and after angiotensin converting enzyme inhibition with captopril (1 and 5 mg/kg). These studies were also repeated on a separate day during simultaneous phenylephrine infusion to prevent a decrease in pressure with captopril. Reduction in sodium intake had no significant effect on arterial pressure, heart rate, or plasma volume, although arterial plasma angiotensin II concentration and renin activity were significantly increased (p less than 0.01). Infusion of angiotensin II produced a signi...Continue Reading

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Citations

Oct 5, 1995·Journal of the Autonomic Nervous System·J Gonzalez GonzalezM Feria Rodriguez
May 6, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·T Zenteno-Savin, M A Castellini
Nov 5, 1999·Clinical and Experimental Pharmacology & Physiology·E MiyajimaM Ishii
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Nov 30, 1999·Anesthesia and Analgesia·P ColsonP Coriat
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·H MurataniK Fukiyama
Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·H MurataniK Fukiyama
Sep 2, 2008·Brain Research·Trasida Ployngam, John P Collister
Dec 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·P Colson
Apr 7, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Casey A MuellerDane A Crossley
Sep 6, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Casey A MuellerDane A Crossley
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter S P TanRoger A L Dampney
Oct 23, 2009·American Journal of Physiology. Cell Physiology·Libin ZhangYu-Long Li

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