Effect of Angiotensin II on Bone Erosion and Systemic Bone Loss in Mice with Tumor Necrosis Factor-Mediated Arthritis.

International Journal of Molecular Sciences
Takahiko AkagiYoshitaka Morita

Abstract

Angiotensin II (Ang II) is the main effector peptide of the renin-angiotensin system (RAS), which regulates the cardiovascular system. The RAS is reportedly also involved in bone metabolism. The upregulation of RAS components has been shown in arthritic synovial tissues, suggesting the potential involvement of Ang II in arthritis. Accordingly, in the present study, we investigated the role of Ang II in bone erosion and systemic bone loss in arthritis. Ang II was infused by osmotic pumps in tumor necrosis factor-transgenic (TNFtg) mice. Ang II infusion did not significantly affect the severity of clinical and histological inflammation, whereas bone erosion in the inflamed joints was significantly augmented. Ang II administration did not affect the bone mass of the tibia or vertebra. To suppress endogenous Ang II, Ang II type 1 receptor (AT1R)-deficient mice were crossed with TNFtg mice. Genetic deletion of AT1R did not significantly affect inflammation, bone erosion, or systemic bone loss. These results suggest that excessive systemic activation of the RAS can be a risk factor for progressive joint destruction. Our findings indicate an important implication for the pathogenesis of inflammatory bone destruction and for the clinic...Continue Reading

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Citations

Nov 5, 2020·International Journal of Molecular Sciences·Chih-Hsin Tang
Aug 22, 2021·Molecular Biology Reports·Fernanda Rocha Chaves MoreiraAna Cristina Simões E Silva

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Methods Mentioned

BETA
X-ray
Polymerase Chain Reaction
PCR

Software Mentioned

- BON
BON
3D
TRI
GraphPad Prism
GraphPad

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