Effect of aniA (carbon flux regulator) and PhaC (poly-beta-hydroxybutyrate synthase) mutations on pyruvate metabolism in Rhizobium etli.

Journal of Bacteriology
M F DunnJ Mora

Abstract

The Rhizobium etli poly-beta-hydroxybutyrate synthase (PhaC) mutant SAM100 grows poorly with pyruvate as the carbon source. The inactivation of aniA, encoding a global carbon flux regulator, in SAM100 restores growth of the resulting double mutant (VEM58) on pyruvate. Pyruvate carboxylase (PYC) activity, pyc gene transcription, and holoenzyme content, which were low in SAM100, were restored in strain VEM58. The genetically engineered overexpression of PYC in SAM100 also allowed its growth on pyruvate. The possible relation between AniA, pyc transcription, and reduced-nucleotide levels is discussed.

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Citations

May 17, 2006·Applied Microbiology and Biotechnology·Maria A Trainer, Trevor C Charles
Oct 1, 2011·Biochemistry·Tonya N ZeczyckiW Wallace Cleland
Jan 28, 2005·Molecular Plant-microbe Interactions : MPMI·E M LodwigP S Poole
Apr 21, 2009·Applied and Environmental Microbiology·Christel SchmeisserWolfgang R Streit
Jun 1, 2002·Applied and Environmental Microbiology·Plamena EntchevaWolfgang R Streit
Feb 7, 2003·Applied and Environmental Microbiology·Elke B Heinz, Wolfgang R Streit
Jan 11, 2011·Journal of Bacteriology·Cristina LandetaDavid Romero
Jun 12, 2002·Journal of Bacteriology·Juan Téllez-SosaMiguel A Cevallos
Mar 27, 2002·Journal of Bacteriology·Sergio EncarnaciónJaime Mora
Jan 2, 2004·Journal of Bacteriology·W R StreitW J Broughton
Jun 15, 2005·Annual Review of Biochemistry·Joanne StubbePinghua Liu
Oct 10, 2007·PLoS Computational Biology·Osbaldo Resendis-AntonioBernhard Ø Palsson
Sep 6, 2017·Molecular Plant-microbe Interactions : MPMI·Justin P HawkinsIvan J Oresnik
Mar 4, 2017·Archives of Microbiology·Niurka MenesesSergio Encarnación

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