Effect of anthocyanin supplementation on cardio-metabolic biomarkers: A systematic review and meta-analysis of randomized controlled trials

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Elnaz DaneshzadK Djafarian

Abstract

Several studies have shown effects of anthocyanin on blood pressure, blood glucose, and lipid profile in different conditions, but the results of these studies are controversial. We summarized evidence from randomized clinical trials (RCTs) that investigated the effects of anthocyanin supplementation on cardio-metabolic biomarkers in adults. The literature searches of MEDLINE and EMBASE for published studies in English was performed up to August 2017. Results were summarized as mean differences (MD) with 95% confidence intervals (CI). Effect sizes of eligible studies were pooled using random-effects models (the DerSimonian-Laird estimator). Heterogeneity among studies was evaluated by the Cochrane Q test. Of 5370 papers, 19 RCTs met inclusion criteria. There was no significant effect of anthocyanin supplementation on weight, waist circumference (WC), body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP). Our results indicated that anthocyanin supplementation had no significant effects on HbA1c (MD: -0.32; 95% CI = -0.64, 0.00; p = 0.050) with no heterogeneity (I2 = 0.0%, p = 0.966, no significant heterogeneity), however anthocyanin supplementation had significant effect on HOMA-IR (MD: -0.21; 95% CI = -0.36...Continue Reading

Citations

Apr 11, 2019·The Proceedings of the Nutrition Society·A BordoniL Tomás-Cobos
Apr 16, 2020·Critical Reviews in Food Science and Nutrition·Banafsheh Jafari AzadAndriko Palmowski
Jul 16, 2020·Current Developments in Nutrition·Theresa F RambaranAnna Nordström
Oct 18, 2020·Nutrients·Gary Williamson, Katherine Sheedy
Oct 20, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Vinicius A do RosarioKaren Charlton
Jun 2, 2021·International Journal of Food Sciences and Nutrition·Rosaria Del GiornoLuca Gabutti
Jul 13, 2021·Journal of Ethnopharmacology·Mohammad Sadegh Adel MehrabanBagher Larijani
Jan 28, 2022·Critical Reviews in Food Science and Nutrition·Alireza Hekmat-ArdakaniNazli Namazi

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