Effect of Anthocyanin Supplementations on Lipid Profile and Inflammatory Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cholesterol
Komal Shah, Pratik Shah

Abstract

To assess combined data from seventeen randomized controlled trials studying effect of anthocyanin consumption on levels of various lipids and inflammatory markers with meta-analysis approach. Various databases, namely, PubMed, MEDLINE, EMBASE, and Cochrane Trial Register were used to identify randomized controlled trials (RCTs) investigating an association between anthocyanins and lipid profile and inflammatory markers. Heterogeneity was assessed using Q and I2 statistics and data was expressed using mean difference with 95% confidence interval. Statistically significant reduction in triglyceride [mean difference (MD) = -9.16, 95% CI: -14.02 to -4.31 mg/dL, I2 = 33.54%, P = 0.149], low density lipoprotein [MD = -8.86, 95% CI: -11.17 to -20.02 mg/dL, I2 = 37.75%, P = 0.098], and apolipoprotein B [MD = -7.13, 95% CI: -8.66 to -5.59 mg/dL, I2 = 20.42%, P = 0.287] levels and increase in high-density lipoprotein [MD = 1.67, 95% CI: 0.8 to 2.54 mg/dL, I2 = 44.88%, P = 0.053] and apolipoprotein A-1 [MD = 6.1, 95% CI: 4.51 to 7.69 mg/dL, I2 = 6.95%, P = 0.358] levels were observed with anthocyanin supplementation. Levels of inflammatory markers were found to reduce [TNF-∞ - MD = -1.98, 95% CI: -2.40 to -1.55 pg/mL, I2 = 0%, P = 0.975;...Continue Reading

References

Jul 13, 2000·Molecular Pathology : MP·S Afford, S Randhawa
May 30, 2007·Molecular Nutrition & Food Research·Shirley Zafra-StoneDebasis Bagchi
Jun 23, 2009·Atherosclerosis·Marco BusnelliMarialuisa Lavitrano
Jul 28, 2010·The Journal of Nutrition·Arpita BasuTimothy J Lyons
Mar 18, 2011·The American Journal of Clinical Nutrition·Mustali M DohadwalaJoseph A Vita
Dec 14, 2011·Atherosclerosis·Santosh Padala, Paul D Thompson
Aug 22, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y ZhuY Yang
May 13, 2014·PloS One·Shashank R JoshiUNKNOWN ICMR-INDIAB Collaborative Study Group
Sep 25, 2015·Journal of the American College of Nutrition·Sergio DavinelliGiovanni Scapagnini

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Citations

Apr 23, 2020·Oxidative Medicine and Cellular Longevity·Maciej DanielewskiTomasz Sozański
Sep 13, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Jaime L ClarkPeter Zahradka
Jun 5, 2021·Free Radical Biology & Medicine·Chelsea Garcia, Christopher N Blesso

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