Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat

Planta medica
Lidia SautebinSalvatore Cuzzocrea

Abstract

Anthocyanins are a group of naturally occurring phenolic compounds related to the colouring of plants, flowers and fruits. These pigments are important as quality indicators, chemotaxonomic markers and for their antioxidant activities. Here we have investigated the therapeutic efficacy of anthocyanins contained in a blackberry extract on (i) circulatory failure, (ii), multiple organ dysfunction and (iii) activity of the inducible isoforms of nitric oxide (NO) synthase (iNOS) and cyclooxygenase (COX-2) in anaesthetised rats with endotoxic shock. In a model of endotoxic shock induced by lipopolysaccharide (LPS, E. coli, 10 mg/kg, i.v.) in the rat, pretreatment with anthocyanins present in the blackberry extract (5 mg/kg, i. v. 30 min before LPS) prevented the hypotension induced by LPS. Endotoxaemia also caused rises in the serum levels of (i) glutamyl oxaloacetic transaminase (GOT), glutamyl pyruvic transaminase (GPT), alkaline phosphates and bilirubin (hepatic dysfunction) (ii) creatinine (renal dysfunction), (iii) amylase and lipase (pancreatic injury), (iii) NOx and 6-keto-PGF1 alpha. Anthocyanins attenuated the hepatic and pancreatic injury, the renal dysfunction and decreased NOx and 6-keto-PGF1 alpha levels. Endotoxaemia f...Continue Reading

Citations

Feb 23, 2011·International Journal of Molecular Sciences·Elizabeth A MazzioKaram F A Soliman
May 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H A Hassan, A F Abdel-Aziz
Jun 23, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hanaa A Hassan, Mokhtar I Yousef
Mar 10, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J DaiR J Mumper
Sep 11, 2012·Molecular Nutrition & Food Research·Marjukka KolehmainenRiitta Törrönen
Mar 7, 2006·Nitric Oxide : Biology and Chemistry·Carlo PergolaLidia Sautebin
Mar 25, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A ZdarilováJ Ulrichová
Dec 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qisen XiangXuebo Liu
Jun 28, 2006·Nutrition and Cancer·Geeta LalaBernadene A Magnuson
Jul 10, 2016·Journal of Complementary & Integrative Medicine·Sarah MousaviMohsen Meidani

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