PMID: 6104696May 1, 1980Paper

Effect of anthraquinone derivatives on canine and rat intestinal motility

The Journal of Pharmacy and Pharmacology
R Garcia-VillarY Ruckebusch

Abstract

The effects on gastrointestinal motility of 3 senna preparations containing 18% oxidized Ca-sennosides, 60% Ca-sennosides, or pure sennosides A + B were tested in dogs and rats as measured by electromyography. Oral administration of the oxidized products in the fasted animal increased the activity of the small intestine within 2 h and reduced both caecal and colonic contractions for 24 h. Severe diarrhoea was present 4-6 h after administration and lasted for at least 1 day. Ca-sennosides had a similar, but weaker effect while pure sennosides affected motility only 6-10 h after oral administration. The intracolonic administration of the oxidized products resulted in an immediate reduction of colon motility for 7-8 h and diarrhoea was present within 40 min. Intracolonic Ca-sennosides and sennosides A + B induced only small changes in the intestinal motility, but diarrhoea also appeared. The results confirm that pure sennosides act predominantly on large intestine motility after their degradation by colonic microorganisms. Oxidized products are already effective in the upper gastrointestinal tract. The early action of Ca-sennosides requires further investigation. Side effects after oral senna treatment such as griping or nausea ma...Continue Reading

References

Jul 1, 1975·The Journal of Physiology·L BuenoY Ruckebusch
Jan 1, 1976·Pharmacology·F H van Os
Jan 1, 1976·Pharmacology·D D Breimer, A J Baars
Jul 1, 1976·The Journal of Clinical Investigation·J R MathiasS Cohen
Mar 1, 1975·The Journal of Physiology·C F Code, J A Marlett
Nov 1, 1975·The American Journal of Digestive Diseases·Y Ruckebusch, L Bueno
Dec 1, 1969·The American Journal of Physiology·J H Szurszewski
Oct 1, 1968·Gut·J D Hardcastle, C V Mann

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Citations

Oct 6, 2005·Archives of Toxicology·J M MitchellJ C Tigner
Jan 1, 1989·Neuroscience·J A Kiernan, E A Heinicke
Mar 6, 2002·Alimentary Pharmacology & Therapeutics·C PicardJ Fioramonti
Feb 13, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C PicardN M Griffiths
Dec 1, 1988·The Journal of Pharmacy and Pharmacology·N MascoloF Capasso
Jul 27, 2007·Basic & Clinical Pharmacology & Toxicology·Michiko KobayashiShingo Yano
Sep 1, 1984·The Journal of Pharmacy and Pharmacology·J FioramontiL Bueno
May 1, 1980·The Journal of Pharmacy and Pharmacology·E Leng-Peschlow
May 1, 1986·The Journal of Pharmacy and Pharmacology·E Leng-Peschlow
Sep 1, 1988·The Journal of Pharmacy and Pharmacology·P De Witte, J Lemli

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