Effect of anti-interleukin 12 treatment on murine lyme borreliosis

The Journal of Clinical Investigation
J AnguitaErol Fikrig

Abstract

The effect of anti-interleukin (IL-12 treatment on Lyme borreliosis in C3H/HeN (C3H) mice was assessed because other studies have implicated CD4+ T cell helper (Th) type 1 responses in the genesis of disease caused by Borrelia burgdorferi. Infection of inbred mice with B. burgdorferi results in varying degrees of arthritis: BALB/c mice develop mild disease and C3H mice develop severe arthritis that is most pronounced 2-4 wk after infection. Since IL-12 is a major inducer of Th1 responses, we blocked this cytokine in vivo in B. burgdorferi infected C3H mice, and evaluated the effects of treatment on the development of arthritis at the peak of acute joint inflammation (14 d) and in the resolution phase (60 d) of disease. As expected, intraperitoneal administration of an anti-IL-12 monoclonal antibody (mAb) to C3H mice resulted in a decrease in both IFN-gamma and B. burgdorferi-specific IgG2a in serum, indicative of diminished Th1 responses. No IL-4 production was detected in serum of anti-IL-12 mAb treated or control mice. IgG1 and IgG2b levels did not increase in B. burgdorferi infected mice treated with anti-IL-12 mAb compared with controls suggesting that Th2 responses were not affected. Nevertheless, CD4+ T cells from both co...Continue Reading

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Citations

Nov 15, 2002·Molecular Immunology·Sean Diehl, Mercedes Rincón
Aug 6, 2002·Medical Hypotheses·D J GrabH-N Lanners
Nov 9, 2002·FEMS Immunology and Medical Microbiology·Juan AnguitaErol Fikrig
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Mar 8, 2018·Emerging Microbes & Infections·Ana Carreras-GonzálezJuan Anguita

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