Effect of anti-Lyb3 antiserum on poly (L-glutamic acid, L-lysine)-induced B cell tolerance

European Journal of Immunology
D H SherrM E Dorf

Abstract

The effect of anti-Lyb3 antiserum on antigen-specific B cell tolerance was investigated. The intraperitoneal injection of the nonimmunogenic copolymer L-glutamic acid60, L-lysine (GL) specifically reduces the ability of murine B cells to form GL-specific plaque-forming cell responses following challenge with the immunogenic conjugate of GL coupled to fowl gamma-globulin. It was found that this tolerance could be reversed or blocked by the intravenous injection of microliter quantities of anti-Lyb3 antiserum. However, this dose of antiserum neither reversed T cell tolerance induced with protein-coupled syngeneic erythrocytes nor induced tolerized B cells to secrete antibody. The results suggest that B lymphocytes can be rescued from GL-induced tolerance soon after induction and that Lyb3 determinants may play a functional role in the activation of antigen-specific B lymphocytes.

References

Jun 1, 1976·The Journal of Experimental Medicine·E S Metcalf, N R Klinman
Feb 1, 1977·The Journal of Experimental Medicine·P W Kincade
Nov 1, 1975·The Journal of Experimental Medicine·F D FinkelmanW E Paul
Apr 1, 1976·The Journal of Experimental Medicine·D H KatzB Benacerraf
Sep 1, 1972·Cellular Immunology·E Diener, M Feldmann
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt

❮ Previous
Next ❯

Citations

Apr 1, 1984·The Journal of Experimental Medicine·D H Sherr, M E Dorf

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.