Effect of antiallergic drugs on interleukin 5-induced eosinophil infiltration of rat airways

Biological & Pharmaceutical Bulletin
Toshiaki TakizawaHiroichi Nagai

Abstract

Interleukin (IL)-5 is thought to play important roles in asthma and to be a potential therapeutic target. An intratracheal injection of murine recombinant IL-5 (3-30 microg/animal) induced a dose-dependent increase in the number of eosinophils in the bronchoalveolar lavage fluid of Brown Norway (BN) rats 24 h after administration. Bovine serum albumin (30pg/animal), used as reference material, did not cause any change. The reaction was not observed in F344 rats. The increase in the number of eosinophils did not accompany bronchial hyperreactivity in BN or F344 rats. Prednisolone (3-10 mg/kg, i.p.) and emedastine (30 mg/kg, p.o.) reduced the increased number of eosinophils induced by the IL-5 challenge. These results suggest that IL-5 is a potent inducer of eosinophils in the airway of BN rats. Prednisolone and emedastine are effective against IL-5-induced eosinophilia.

References

Jan 1, 1979·International Archives of Allergy and Applied Immunology·R PauwelsM Van Der Straeten
Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Jan 1, 1992·British Journal of Pharmacology·T IwamaA Koda
May 1, 1991·The Journal of Clinical Investigation·Q HamidP K Jeffery
Dec 1, 1994·Current Opinion in Immunology·M C Seminario, G J Gleich
Apr 1, 1993·The American Review of Respiratory Disease·P M RenziJ G Martin
Jan 1, 1996·The Journal of Experimental Medicine·J M DrazenK F Austen
Sep 1, 1996·American Journal of Respiratory Cell and Molecular Biology·P M RenziQ Hamid
Nov 1, 1996·Immunopharmacology and Immunotoxicology·A E el-ShazlyT Ishikawa
Mar 1, 1997·American Journal of Respiratory Cell and Molecular Biology·H ShiC Zhang
Dec 31, 1997·American Journal of Respiratory Cell and Molecular Biology·T SchneiderA C Issekutz
Sep 9, 1998·The American Journal of Physiology·T Adachi, R Alam
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·H MishimaJ G Martin
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·L M TeranJ M Schröder
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A W MouldP S Foster
Apr 11, 2000·The Journal of Allergy and Clinical Immunology·G J Gleich
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·B P EnglandM McKinnon
Nov 4, 2000·Expert Opinion on Investigational Drugs·J K Weltman, A S Karim
Jan 12, 2001·American Journal of Respiratory Cell and Molecular Biology·L D MikusR F Lemanske
Jun 16, 2001·International Archives of Allergy and Immunology·H SaitoK Takahashi

❮ Previous
Next ❯

Citations

Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroichi NagaiTeruo Tuchiya
Dec 28, 2006·International Archives of Allergy and Immunology·Miaw-Ling Chen, Bi-Fong Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.