Effect of antibiotics on clinical, pathologic and immunologic responses in murine Potomac horse fever: protective effects of doxycycline

Veterinary Microbiology
Y Rikihisa, B M Jiang

Abstract

Effects of three antibiotics on clinical, pathologic and immunologic responses in murine Potomac horse fever caused by Ehrlichia risticii infection were examined. When antibiotics were given after the development of clinical signs, antibiotics ranked in the order of reducing clinical signs and in preventing body weight loss and an intestinal enlargement were doxycycline, demeclocycline and rifampin. Infected mice treated with doxycycline and demeclocycline developed greater splenomegaly than rifampin-treated or untreated infected mice. All antibiotics used prevented thymic atrophy due to E. risticii infection. Indirect fluorescent antibody titers were highest with doxycycline treatment. Mice treated with demeclocycline and rifampin produced higher antibody titer than those without treatment. Ehrlichia risticii was reisolated from the spleens of both untreated and rifampin-treated infected mice. The effects of administering single doses of doxycycline at different times after infection were examined. Body weight loss was prevented by the drug given at every treatment day examined, i.e. Days 3, 5 and 7 post-infection (PI). Thymic atrophy was minimum in mice treated at Day 5 PI, while splenomegaly was found on every treatment day....Continue Reading

References

Jul 1, 1988·Antimicrobial Agents and Chemotherapy·Y Rikihisa, B M Jiang

❮ Previous
Next ❯

Citations

Jul 1, 1993·Veterinary Microbiology·Y RikihisaS Yamamoto
Nov 1, 1991·Equine Veterinary Journal·P Mulville
Feb 4, 2006·American Journal of Veterinary Research·Jennifer L DavisMark G Papich
Feb 1, 1994·Journal of Comparative Pathology·N M Williams, P J Timoney
Sep 25, 2010·Veterinary Ophthalmology·Carmen M H ColitzJens Christian Rudnick
Jan 27, 2004·The Veterinary Clinics of North America. Equine Practice·Mark G Papich
Jul 1, 1991·Clinical Microbiology Reviews·Y Rikihisa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.