Effect of antibody on entry of Rickettsia tsutsugamushi into polymorphonuclear leukocyte cytoplasm.

Infection and Immunity
Y Rikihisa, S Ito

Abstract

The effects of rickettsial antibodies on the entry of Rickettsia tsutsugamushi, Gilliam strain, into guinea pig polymorphonuclear leukocyte cytoplasm were studied by electron microscopy. Immunoglobulin G fractions were obtained from four rabbit antisera against: yolk sac-propagated rickettsiae; baby hamster kidney cell (BHK-21)-propagated rickettsiae; formaldehyde-fixed, BHK-21 cell-propagated rickettsiae; and glutaraldehyde-fixed, BHK-21 cell-propagated rickettsiae. A fuzzy coating was observed on the rickettsiae after reaction with each of the antibodies. All of the antibodies increased the uptake of rickettsiae by polymorphonuclear leukocytes. The opsonization effect was higher with an antibody against BHK-21 cell-propagated rickettsiae than with an antibody against yolk sac-propagated rickettsiae, and an antibody to live rickettsiae had a higher opsonization effect than did antibodies to chemically fixed rickettsiae. Rickettsiae were released from phagosomes into the cytoplasm with the four antibodies. The highest number of rickettsiae were released into the cytoplasm with antibody against live rickettsiae propagated in BHK-21 cells. The four antibodies inhibited the translocation of the cytoplasmic rickettsiae from the fil...Continue Reading

References

Sep 19, 1979·The Journal of Experimental Medicine·Y Rikihisa, S Ito
Nov 1, 1979·Infection and Immunity·C A Nacy, J V Osterman
Oct 1, 1982·Infection and Immunity·Y Rikihisa, S Ito
Mar 1, 1946·Proceedings of the Society for Experimental Biology and Medicine·J E SMADELE B JACKSON

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Citations

May 1, 1991·European Journal of Epidemiology·A TamuraN Ohashi
Jul 2, 2009·FEMS Microbiology Letters·Sun-Myoung LeeJae-Seung Kang
Aug 9, 2013·The American Journal of Tropical Medicine and Hygiene·Daniel H ParisDavid H Walker
Jan 21, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel H ParisAllen L Richards
Feb 13, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynn Soong
Feb 28, 2001·Microbes and Infection·S Y SeongI S Kim
Oct 1, 1983·Infection and Immunity·B A Hanson

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