Effect of Anticitrullinated Protein Antibody Status on Response to Abatacept or Antitumor Necrosis Factor-α Therapy in Patients with Rheumatoid Arthritis: A US National Observational Study

The Journal of Rheumatology
Leslie R HarroldJoel M Kremer

Abstract

Assess whether baseline anticyclic citrullinated peptide antibodies (anti-CCP) status is associated with treatment response in patients with rheumatoid arthritis (RA) initiating abatacept (ABA) or a tumor necrosis factor-α inhibitor (TNFi). Using the Corrona RA registry, patients were identified who initiated ABA or a TNFi (June 2004-January 2015), had a followup visit 6 months (± 3 mos) after initiation, and anti-CCP measured at or prior to initiation. Primary outcome was mean change in Clinical Disease Activity Index (CDAI) from initiation to 6 months. Treatment response was evaluated based on a typical patient profile (female, aged 57 yrs, body mass index of 30 kg/m2, baseline CDAI of 20, 1 prior biologic, and no comorbidities other than RA). Secondary outcomes included remission and low disease activity. There were 566 ABA initiators [anti-CCP+ (≥ 20 units/ml): n = 362; anti-CCP- (< 20 units/ml): n = 204] and 1715 TNFi initiators (anti-CCP+: n = 1113; anti-CCP-: n = 602). Differences between treatment groups included baseline disease duration, CDAI, and prior biologic use. At 6 months, anti-CCP+ ABA initiators were associated with significantly greater CDAI response versus anti-CCP- ABA initiators; no significant difference...Continue Reading

References

Mar 7, 2002·Arthritis Research·Martinus A M van BoekelWalther J van Venrooij
Sep 29, 2005·Rheumatology·A J W ZendmanG J M Pruijn
Oct 7, 2005·Arthritis Research & Therapy·Annette H M van der Helm-van MilTom W J Huizinga
Aug 3, 2010·Seminars in Arthritis and Rheumatism·Jeffrey R CurtisAngela Zink
Apr 3, 2012·The Journal of Rheumatology·Benjamin A FisherUNKNOWN Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS)
Nov 8, 2015·Arthritis & Rheumatology·Jasvinder A SinghTimothy McAlindon

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Citations

Jun 17, 2018·Journal of Internal Medicine·R F van Vollenhoven
Oct 5, 2019·Journal of Personalized Medicine·Ben MulhearnSebastien Viatte
Mar 31, 2021·Expert Review of Proteomics·Anne C Bay-JensenClaus H Nielsen
Sep 15, 2021·Rheumatology and Therapy·Markus RehbergUNKNOWN MOBILITY, MONARCH, TARGET, and ASCERTAIN investigators
Jan 8, 2022·The Journal of Applied Laboratory Medicine·Janet MartinWaliul I Khan

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