PMID: 15232331Jul 3, 2004Paper

Effect of antidepressant medication resistance on short-term response to electroconvulsive therapy

Journal of Clinical Psychopharmacology
Walter W van den BroekJan A Bruijn

Abstract

This prospective study assessed the influence of resistance to antidepressant pharmacotherapy on the short-term response to subsequent electroconvulsive therapy (ECT). Previous research has shown that patients with medication resistance were less likely to respond to ECT. This finding may be applicable to the population of depressed inpatients in The Netherlands, where ECT is often preceded by several medication trials. Eighty-five patients (61 female and 24 male patients) with DSM-IV criteria for depressive disorder, both with and without mood congruent psychotic features, were included for analysis. Medication resistance was rated with the Antidepressant Treatment History Form. Medication resistance was predefined in accordance with the previous research in this field. When a reduction of at least 50% on the 17-item version of the Hamilton Rating Scale for Depression (HRSD) between pre- and post-ECT is used as response criterion, medication-resistant patients were equally likely to respond to subsequent ECT (30/48 = 82.5%) than patients without medication resistance (30/37 = 81.1%). Even when post-ECT HRSD score < or = 7 was used (full remission), there was no significant difference between medication-resistant patients (21/4...Continue Reading

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Citations

Jun 7, 2005·Journal of Affective Disorders·Iris M de VreedeIrene M van Vliet
Aug 30, 2005·The Journal of ECT·W Vaughn McCall, Max Fink
Nov 23, 2005·The Journal of ECT·Tom K BirkenhägerAriejan de Lely
Sep 4, 2010·Journal of Clinical Psychopharmacology·Willemijn T HeijnenWalter W van den Broek
Apr 2, 2010·The Journal of ECT·Stephen H Dinwiddie, Deborah Spitz
Oct 22, 2010·Journal of Affective Disorders·Colleen K LooDusan Hadzi-Pavlovic
Aug 1, 2015·The Cochrane Database of Systematic Reviews·Jaap WijkstraWillem A Nolen
Jul 25, 2019·Acta Psychiatrica Scandinavica·K PopiolekA Nordenskjöld
Jan 1, 2019·Journal of Affective Disorders·Takafumi WatanabeEisuke Matsushima

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