PMID: 515Nov 1, 1975

Effect of antihistamine-antiserotonin and ganglionic blocking agents upon increased capillary permeability following burn trauma

The Journal of Trauma
H F CarvajalH A Linares


Tiny (0.2% TBS), partial thickness, non-contact radiant heat burns in guinea pigs resulted, within 3 hours, in significant edema formation and protein leakage at the site of the injury. Areas of skin distant to the burn also showed an increase in water content but no protein leakage. Pretreatment of the animals with either chlorisondamine hydrochloride or a mixture of methysergide and chlorpheniramine significantly decreased postburn edema formation and protein leakage. Liquid emulsion autoradiography revealed that leakage of protein occurs primarily in the areas of skin adjacent to the panniculus carnosus. The studies suggest that: the increase in vascular permeability that occurs as a consequence of burn injuries is humorally mediated; albumin leakage is limited to the injured tissues; and histamine, serotonin, and presumably catecholamines play significant roles in the development of this phenomenon.


Jun 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H F Carvajal
Feb 9, 2002·Burns : Journal of the International Society for Burn Injuries·Kiho ChoDavid G Greenhalgh
Nov 24, 1999·Burns : Journal of the International Society for Burn Injuries·H TanakaS Shimazaki
Jul 24, 1998·Burns : Journal of the International Society for Burn Injuries·O LöfgrenT Lundeberg
Aug 4, 1998·Burns : Journal of the International Society for Burn Injuries·A JönssonJean Cassuto
Jan 1, 1992·World Journal of Surgery·G D Warden
Aug 5, 2009·Wiener medizinische Wochenschrift·Maike KeckMarc G Jeschke
Jan 1, 1984·Scandinavian Journal of Plastic and Reconstructive Surgery·I Blomgren, U Bagge
Jun 15, 2012·Burns : Journal of the International Society for Burn Injuries·Yan T Ortiz-PomalesBrian P Eliceiri
Jan 30, 2008·Burns : Journal of the International Society for Burn Injuries·Anders SamuelssonFolke Sjöberg
May 20, 1998·Current Problems in Pediatrics·R L Sheridan
Feb 3, 2005·Burns : Journal of the International Society for Burn Injuries·Jean CassutoJohanna Räntfors
Mar 1, 1978·Microvascular Research·B H BrouhardH A Linares
Oct 1, 1981·The Journal of Surgical Research·B A HarmsR H Demling
Sep 25, 2001·Current Problems in Surgery·R L Sheridan
May 15, 2013·Microvascular Research·Jochen Frederick HernekampThomas Kremer
Sep 8, 2016·Critical Care Clinics·Lisa RaeNicole Gibran
Nov 28, 1985·The New England Journal of Medicine·R H Demling
May 1, 1982·Burns, Including Thermal Injury·L B Nanney
May 1, 1996·The Journal of Trauma·C S ChuB A Pruitt
Jul 1, 1997·Pediatric Surgery International·S E WolfD N Herndon
Feb 11, 2009·The Journal of Trauma·Zoltan BakBirgitta Janerot-Sjoberg
Aug 1, 2007·Journal of Burn Care & Research : Official Publication of the American Burn Association·David G Greenhalgh
Jan 1, 1992·World Journal of Surgery·T LundR K Reed
Jan 1, 1988·Intensive Care Medicine·C DhenninJ F Feauveaux

Related Concepts

Body Water
Burn Injury
Vascular Permeability
Drug Combinations
Ganglionic Blockers
Cavia porcellus
Antihistamines, Classical

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