PMID: 4890523May 24, 1969Paper

Effect of antihypertensive drugs on the "intrinsic" heart rate

British Medical Journal
A Káldor, P Juvancz

Abstract

"Intrinsic" heart rate in man was measured by giving simultaneous atropine and propranolol and used to study the direct effect of antihypertensive drugs on the heart. Though the intrinsic and control heart rates decreased significantly following the administration of reserpine, there was no significant difference between high and low doses. No similar effects were observed with debrisoquine sulphate and methyldopa, though in high doses the latter produced a decrease which was of some statistical significance.

References

Dec 30, 1967·Lancet·J R SuttonW A Seldon
Apr 14, 1962·Lancet·R I BAYLISS, E A HARVEY-SMITH
Apr 14, 1962·Lancet·C T DOLLERY, M HARINGTON

❮ Previous
Next ❯

Citations

Aug 1, 1976·Postgraduate Medical Journal·S Talbot, G W Gill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.