Effect of antihypertensive treatment on cardiac and subcutaneous artery structure: a comparison between calcium channel blocker and thiazide-based regimens

American Journal of Hypertension
I SihmO Lederballe

Abstract

The effects of two antihypertensive regimens (isradipine and hydrochlorothiazide-amiloride) on the ratio between media thickness and lumen diameter of subcutaneous arteries and on left ventricular mass in essential hypertension were compared. Fifty patients, aged 46.3+/-8 (mean+/-SD) years, with newly diagnosed or poorly controlled essential hypertension were randomized to treatment with either isradipine or hydrochlorothiazide-amiloride. Atenolol and hydralazine were added in both groups as secondary and tertiary drugs, respectively, when needed for normalization of diastolic blood pressure. A subcutaneous gluteal biopsy was taken surgically before medication and again after 9 months of successful antihypertensive treatment. Two small resistance arteries were isolated from each biopsy and mounted in a Mulvany-Halpem isometric small vessel myograph. The media thickness-to-lumen diameter ratio (percentage) of the vessels was measured under standardized conditions and meaned. Left ventricular mass (LVM) index was determined by echocardiography according to the Penn convention. Ten patients were treated with isradipine as monotherapy, whereas only one patient was well controlled on diuretics as monotherapy. Mean blood pressure was...Continue Reading

Citations

Feb 25, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Olga KudryavtsevaChristian Aalkjær
May 10, 2007·The Journal of Clinical Endocrinology and Metabolism·Hylton V JoffeGail K Adler
Mar 19, 2009·Journal of Hypertension·Enrico Agabiti-RoseiDamiano Rizzoni
Sep 20, 2008·Blood Pressure·Gianluca E M BoariEnrico Agabiti Rosei
Apr 8, 2006·Current Hypertension Reports·Damiano Rizzoni, Enrico Agabiti Rosei
Sep 17, 2011·Basic & Clinical Pharmacology & Toxicology·Kent L Christensen, Niels H Buus
Jun 22, 2013·Journal of Hypertension·Chelvin C A SngTien Y Wong
Mar 28, 2020·American Journal of Hypertension·Ko Jin QuekJacqueline K Phillips
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ernesto L Schiffrin, Rhian M Touyz
Apr 7, 2007·Journal of Hypertension·Ole N MathiassenKent L Christensen
Jan 30, 2008·Medical & Biological Engineering & Computing·Michael J Mulvany

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